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Informationen zum Autor SHAYNE COX GAD, PHD, DABT, ATS, is the Principal of Gad Consulting Services. Dr. Gad has more than thirty years of experience as a toxicologist, statistical consultant, manager, and general consultant on research and development in the chemical, consumer product, contract testing, biotechnology, medical device, and pharmaceutical industries. He is the author of thirty- four books and numerous papers, presentations, and other publications. Klappentext A clear, straightforward resource to guide you through preclinical drug developmentFollowing this book's step-by-step guidance, you can successfully initiate and complete critical phases of preclinical drug development. The book serves as a basic, comprehensive reference to prioritizing and optimizing leads, dose formulation, ADME, pharmacokinetics, modeling, and regulations. This authoritative, easy-to-use resource covers all the issues that need to be considered and provides detailed instructions for current methods and techniques.Each chapter is written by one or more leading experts in the field. These authors, representing the many disciplines involved in preclinical toxicology screening and testing, give you the tools needed to apply an effective multidisciplinary approach. The editor has carefully reviewed all the chapters to ensure that each one is thorough, accurate, and clear.Among the key topics covered are:*Modeling and informatics in drug design*Bioanalytical chemistry*Absorption of drugs after oral administration*Transporter interactions in the ADME pathway of drugs*Metabolism kinetics*Mechanisms and consequences of drug-drug interactionsEach chapter offers a full exploration of problems that may be encountered and their solutions. The authors also set forth the limitations of various methods and techniques used in determining the safety and efficacy of a drug during the preclinical stage.This publication should be readily accessible to all pharmaceutical scientists involved in preclinical testing, enabling them to perform and document preclinical safety tests to meet all FDA requirements before clinical trials may begin. Zusammenfassung This book gives the professional pharmaceutical scientist a basic and comprehensive tool to facilitate the preclinical development process by bringing together an overview of the preclinical process and a compendium of methods and techniques that need to be considered when developing a new drug. Inhaltsverzeichnis Preface xv 1 Modeling and Informatics in Drug Design 1 Prasad V. Bharatam, Smriti Khanna, and Sandrea M. Francis 2 Computer Techniques: Identifying Similarities Between Small Molecules 47 Peter Meek, Guillermo Moyna, and Randy Zauhar 3 Protein-Protein Interactions 87 Kamaljit Kaur, Dipankar Das, and Mavanur R. Suresh 4 Method Development for Preclinical Bioanalytical Support 117 Masood Khan and Naidong Weng 5 Analytical Chemistry Methods: Developments and Validation 151 Izet M. Kapetanovic and Alexander V. Lyubimov 6 Chemical and Physical Characterizations of Potential New Chemical Entity 211 Adegoke Adeniji and Adeboye Adejare 7 Permeability Assessment 227 Srinivas Ganta, Puneet Sharma, and Sanjay Garg 8 How and Where Are Drugs Absorbed? 249 Marival Bermejo and Isabel Gonzalez-Alvarez 9 Absorption of Drugs after Oral Administration 281 Luis Granero and Ana Polache 10 Distribution: Movement of Drugs through the Body 323 Jayanth Panyam and Yogesh Patil 11 The Blood-Brain Barrier and Its Effect on Absorption and Distribution 353 A. G. de Boer and P. J. Gaillard 12 Transporter Interactions in the ADME Pathway of Drugs 407 Yan Zhang and Donald W. Miller 13 Accumulation of Drugs in Tissues 429 Krishn...
