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Recent developments in occupational asthma research and clinical practice are the focus of this publication. It discusses the contribution of occupational exposures to chemical and biological agents to the burden of asthma in adults, powerful approaches like the use of apprentices studies, which include young individuals, naïve with regard to occupational exposures, and diagnostic criteria for work related and work aggravated asthma. Specific emphasis is given to exposure response relationships for allergen exposure, large gene-environment studies and whole genome screening approaches. Management, prevention and surveillance are covered as well. Diagnostic rules are introduced to rationalize the diagnostic workup and improve the cost benefit of surveillance schemes. Issues in the design of population studies are discussed to assist the readers in designing and conducting their own study. This comprehensive volume presents new developments changing the occupational asthma field in the coming years.
Table des matières
The history of research on asthma in the workplace - Development, victories and perspectives.- Epidemiology and risk factors of occupational respiratory asthma and occupational sensitization.- Epidemiology of laboratory animal allergy.- Population-attributable fraction for occupation and asthma.- Definition and diagnosis of occupational asthma.- Work-exacerbated asthma.- Natural history and prognosis.- Mechanisms of allergic occupational asthma.- Mechanisms of occupational asthma caused by low-molecular-weight chemicals.- Asthma-like diseases in agriculture.- Allergen and irritant exposure and exposure-response relationships.- Gene-environment interactions in occupational asthma.- Asthma in apprentice workers The birth cohort parallel: Using apprentices as a powerful cohort design for studying occupational asthma.- Management of an individual worker with occupational asthma.- Social consequences and quality of life in work-related asthma.- Prevention of work-related asthma seen from the workplace and the public health perspective.- Prevention and regulatory aspects of exposure to asthmagens in the workplace.- Design, conduct and analysis of surveys on work-related asthma.
Résumé
Recent developments in occupational asthma research and clinical practice are the focus of this publication. It discusses the contribution of occupational exposures to chemical and biological agents to the burden of asthma in adults, powerful approaches like the use of apprentices studies, which include young individuals, naïve with regard to occupational exposures, and diagnostic criteria for work related and work aggravated asthma. Specific emphasis is given to exposure response relationships for allergen exposure, large gene-environment studies and whole genome screening approaches. Management, prevention and surveillance are covered as well. Diagnostic rules are introduced to rationalize the diagnostic workup and improve the cost benefit of surveillance schemes. Issues in the design of population studies are discussed to assist the readers in designing and conducting their own study. This comprehensive volume presents new developments changing the occupational asthma field in the coming years.
Texte suppl.
From the reviews:
“The editors of this book weave together developments in the field of occupational asthma research and clinical practice and further investigate the contribution of occupational exposures to both chemical and biological agents. … Reasonably speaking, the reach of this book goes … cohort of occupational asthma researchers to a much wider range of clinicians, basic scientists, and toxicologists. … this book is important in increasing knowledge and effectiveness among clinicians and related engineering personnel who must prevent occupational asthma from occurring.” (J. Thomas Pierce, Doody’s Review Service, April, 2011)
Commentaire
From the reviews:
"The editors of this book weave together developments in the field of occupational asthma research and clinical practice and further investigate the contribution of occupational exposures to both chemical and biological agents. ... Reasonably speaking, the reach of this book goes ... cohort of occupational asthma researchers to a much wider range of clinicians, basic scientists, and toxicologists. ... this book is important in increasing knowledge and effectiveness among clinicians and related engineering personnel who must prevent occupational asthma from occurring." (J. Thomas Pierce, Doody's Review Service, April, 2011)
