Iron Acquisition by the Genus Mycobacterium - History, Mechanisms, Role of Siderocalin, Anti-Tuberculosis Drug Development

Iron Acquisition by the Genus Mycobacterium summarizes the early evidence for the necessity of iron in mycobacteria and the discovery of the mycobacterial siderophores mycobactin, carboxymycobactin, and exochelin. The structural characterization of the mycobacterial siderophores is described. The genes so far identified as essential for iron acquisition and maintenance of an infection by pathogenic mycobacteria are discussed. The potential role of siderocalin in iron gathering by M. tuberculosis is featured. Because new drugs for M. tuberculosis are needed, this brief also emphasizes the design of antibiotics that interfere with siderophore biosynthesis and the use of siderophore analogs and/or conjugates.

Table des matières

A History of Iron Metabolism in the Mycobacteria.- Mycobacterial Iron Uptake Mechanisms.- Siderocalin Combats Mycobacterial Infections.- Design of Anti-TB Drugs Using the Iron Uptake Platform.

Résumé

Iron Acquisition by the Genus Mycobacterium summarizes the early evidence for the necessity of iron in mycobacteria and the discovery of the mycobacterial siderophores mycobactin, carboxymycobactin, and exochelin. The structural characterization of the mycobacterial siderophores is described.  The genes so far identified as essential for iron acquisition and maintenance of an infection by pathogenic mycobacteria are discussed.  The potential role of siderocalin in iron gathering by M. tuberculosis is featured. Because new drugs for M. tuberculosis are needed, this brief also emphasizes the design of antibiotics that interfere with siderophore biosynthesis and the use of siderophore analogs and/or conjugates.

Détails du produit

• Collaboration: B. Rowe Byers (Editeur)
• Edition: Springer, Berlin
• Langues: Anglais
• Format d'édition: Livre de poche
• Sortie: 03.06.2013
• EAN: 9783319003023
• ISBN: 978-3-31-900302-3
• Pages: 92
• Dimensions: 152 mm x 238 mm x 8 mm
• Poids: 166 g
• Illustrations: V, 92 p. 39 illus., 9 illus. in color.
• Thèmes: SpringerBriefs in Molecular Science; SpringerBriefs in Biometals
• Catégories: Sciences naturelles, médecine, informatique, technique > Biologie > Microbiologie; Anorganische Chemie, Biochemie, Organische Chemie, C, Krankheiten und Störungen, Life Sciences, Diseases, INTERNAL MEDICINE, biochemistry, microbiology, Infectious & contagious diseases, proteins, infectious diseases, Biomedical and Life Sciences, Inorganic Chemistry, Bioorganic Chemistry, Diseases and disorders, Protein-Ligand Interactions