En savoir plus
Tremendous progress has been made in understanding the pathophysiology of ischemic heart disease. As a result, new therapeutic approaches for protecting the heart from ischemic injury are in development.
This volume will highlight issues concerning basic mechanisms of ischemia-reperfusion injury in relation to potential therapeutic strategies.
Table des matières
Preface.- Introduction: From Fetal to Fatal: Metabolic adaptation of the heart to environmental stress.- Myocardial Ischemia: Basic concepts.- Hormones Signaling and Myocardial Ischemia.- Ischemic Preconditioning.- Connexin 43 and Ischemic Preconditioning.- Coronary Microembolization.- Fibroblast Growth Factor-2.- Myocardial Protection - From Concepts to Clinical Practice.- A Synopsis.- Index.
Résumé
Effective new treatments of heart disease are based on a refined understanding of cellular function and the heart's response to environmental stresses. Not surprisingly therefore, the field of experimental cardiology has experienced a phase of rapid exponential growth during the last decade. The acquisition of new knowledge has been so fast that textbooks of cardiology or textbooks of cardiovascular physiology are often hard-pressed to keep up with the most important conceptual advances. Witness the explosive increase in knowledge about signaling pathways of cardiac growth, transcriptional regulation of cardiac metabolism, hormonal signaling, and the complex responses of the heart to ischemia, reperfusion, or ischemic preconditioning. This book is meant to bridge the gap between original literature and textbook reviews. It brings together investigators of various backgrounds who share their expertise in the biology of myocardial ischemia. Each chapter is a self-contained mini-review, but it will soon become apparent to the reader that there is also a common thread: Molecular and cellular cardiology has never been more exciting than now, but ever more exciting times are yet to come.
Dr. Dennis V. Cokkinos, MD, PhD, is a Professor of Cardiology at the University of Athens and Chairman of the Cardiology Department at Onassis Cardiac Surgery Center, Athens, Greece.
Dr. Constantinos I. Pantos, MD, PhD, is an Assistant Professor of Pharmacology, Department of Pharmacology, Medical School, University of Athens, Athens, Greece.
Gerd Heusch, MD, PhD, is a Professor of Medicine and Director of the Institute of Pathophysiology, Department of Internal Medicine, University of Essen, Essen, Germany.
Heinrich Taegtmeyer, MD, DPhil, is a Professor of Medicine and Co-Director of the Division of Cardiology, The University of Texas, Houston Medical School, Houston, Texas, USA.
