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Precision pathology of cancer is a new frontier - a systemic diagnostic approach to provide specific therapeutic targets and genetic and metabolic information for the treatment of patients. Not only are cancers extremely diverse but there is also heterogenetic variation among patients with the same cancer; owing to differences in genetic makeup and metabolic levels, a drug may work in one patient but be toxic in another. This text covers both basic concepts (the role of the precision pathologist, ethical issues, molecular basis, tools used in precision pathology, and specimen procurement) and clinical practice (the precise genes/pathways, ongoing clinical trials, therapeutics, pharmacogenomics, pharmacoproteomics, and pharmacometabolomics) in precision pathology of cancer.
- Covers both the conceptual bases and the clinical applications
- Enables pathologists, haematologists, and medical oncologists to apply Precision Pathology to their daily clinical practice
- Covers the whole range of cancers in practical detail
Table des matières
Preface.List of Contributors.1. Precision Pathology
. 2. The Role of Precision Pathologist
. 3. Ethical Issues in Precision Pathology
. 4. Molecular Basis of Precision Pathology
. 5. Tools in Precision Pathology
. 6. Specimen Acquisition
. 7. Skin Cancer
. 8. Bone and Soft Tissue Tumors
. 9. Primary Central Nervous System Tumor
. 10. Head and Neck Cancer
. 11. Lung Cancer
. 12. Mesothelioma
. 13. Breast Cancer
. 14. Gastrointestinal System Carcinomas
. 15. Hepatobiliary and Pancreatic Cancer
. 16. Urinary and Male Genital Tract Tumor
. 17. Female Reproductive System Tumors
. 18. Neuroendocrine Neoplasms
. 19. Myeloid Neoplasms
. 20. Lymphoid Neoplasms
.Index.
A propos de l'auteur
Xianfeng F. Zhao, MD PhD MBA, is Professor and Chair, Department of Pathology and Laboratory Medicine at the University of Tennessee Health Science Center College of Medicine, Memphis, Tennessee
Shiyong Li, MD PhD, is the Professor and Director of Hematopathology, Department of Pathology and Laboratory Medicine at the Emory University School of Medicine, Atlanta, Georgia.
Résumé
The text covers both basic concepts (the role of the precision pathologist, ethical issues, molecular basis, tools used in precision pathology, and specimen procurement) and clinical practice (the precise genes/pathways, ongoing clinical trials, therapeutics, pharmacogenomics, pharmacoproteomics, and pharmacometabolomics).
