THE IMPACT OF HYPOXIA ON THE IN VITRO EXPANSION OF T AND NK CELLS - THE IMPACT OF HYPOXIA ON THE IN VITRO EXPANSION OF T AND NATURAL KILLER (NK) CELLS

Infusions of T cells and NK cells (Natural Killer) from peripheral blood are being carried out to treat malignancies. Lymphocytes propagated ex vivo, in normoxia (20% O2), are infused intravenously and must survive the hypoxia associated with venous circulation, bone marrow (5% O2) and the tumor microenvironment (1% O2). The main objective of this study was to determine the proliferative capacity of human T and NK cells in normoxia (20% O2) versus hypoxia (1% O2), for 28 days, using an artificial antigen-presenting cell (aAPC) for clinical grade propagation.

A propos de l'auteur

Licenciado en Biología por la PUCRS. Especialización en Biología Molecular Aplicada al Área de la Salud por la ULBRA y Maestría por el Programa de Postgrado en Medicina de la UFRGS. Doctorado sándwich en la Universidad de Texas/MDAnderson Cancer y Postdoctorado en el Laboratorio de Señalización y Plasticidad Celular/UFRGS.

Détails du produit

• Auteurs: Bruna Amorin, Maria Aparecida Lima da Silva, Annelise Pezzi
• Edition: Our Knowledge Publishing
• Langues: Anglais
• Format d'édition: Livre de poche
• Sortie: 21.01.2024
• EAN: 9786206944973
• ISBN: 9786206944973
• Pages: 52
• Catégorie: Sciences naturelles, médecine, informatique, technique > Médecine > Général