Human Immunodeficiency Virus - Biology, Immunology, and Therapy

The past few years have witnessed an explosive increase in our collective knowledge of the biology of the human immunodeficiency virus (HIV). Researchers have acquired new understanding of the virus's biochemistry, molecular biology, pathogenesis, genetics, and immunobiology. Resulting therapeutic advances have significantly prolonged the lives of thousands. Yet, the need to develop better therapies is ever more acute and--given the virus's continued spread through the human population--the need for an effective vaccine is urgent.

These goals can be accomplished only through the experienced synthesis of information from the many disciplines participating in HIV research and through the insights of new investigators. This volume is designed to lower the barriers imposed on investigators by the sheer volume of available information--information that often can be found only in far-flung and specialized journals. It provides, in a single resource, an in-depth overview of the diverse areas that constitute HIV research. The result is a broad introduction for students and researchers new to the field as well as an integrated overview for researchers specialized in particular areas of HIV investigation. The volume will also benefit those seeking technical understanding of the virus's biology, including physicians treating HIV-infected patients.

Each chapter is a comprehensive presentation of one area of current AIDS research--including work on the virus life cycle, epidemiology, genetics, protease and reverse transcriptase inhibitors, receptor and co-receptor interactions, therapeutic targets, clinical treatment, immunobiology, and vaccines--written by a leading researcher in that area. The contributors are Jon P. Anderson, Jan Balzarini, Elana Cherry, Thomas J. Coates, Chris Collins, Jon H. Condra, Mark B. Feinberg, Richard B. Gaynor, Matthias Götte, Daria J. Hazuda, Spyros Kalams, Nathaniel R. Landau, Gerald H. Learn, Norman L. Letvin, James I. Mullins, Willscott E. Naugler, David Nickle, Matthew Rain, Allen G. Rodrigo, Daniel Shriner, Shalom Spira, Mario Stevenson, Todd Summers, Catherine Ulich, Joseph P. Vacca, Mark A. Wainberg, Bruce D. Walker, and Yang Wang.

Table des matières

Preface vii
Contributors xi
Chapter 1
The Structure and Biology of HIV 1: Introduction by Elana Cherry and Mark A. Wainberg
Chapter 2
The Genetics of HIV-1 by Jon P. Anderson, Matthew Rain, Daniel Shriner, Allen G. Rodrigo, Yang Wang, David Nickle, Gerald H. Learn, Willscott E. Naugler, and James I. Mullins 44
Chapter 3
Nucleoside Inhibitors of HIV Reverse Transcriptase and the Problem of Drug Resistance by Matthias Gdtte, Shalom Spira, and Mark A. Wainberg 100
Chapter 4
Non-Nucleoside Reverse Transcriptase Inhibitors of HIV-1 by Jan Balzarini 132
Chapter 5
HIV -1 Protease Inhibitors by Jon H. Condra and Joseph P. Vacca 172
Chapter 6
The Biology and Biochemistry of Integration as a Target for Chemotherapeutic Intervention by Daria J. Hazuda 223
Chapter 7
Chemokine Receptors in HIV Infection and AIDS by Nathaniel R. Landau 250
Chapter 8
Novel HIV-1 Therapeutic Targets: Regulatory Functions by Catherine Ulich and Richard B. Gaynor 294
Chapter 9
Novel HIV -1 Therapeutic Targets: Accessory Functions by Mario Stevenson 328
Chapter 10
The Interface between the Pathogenesis and Treatment of HIV Infection by Mark B. Feinberg 384
Chapter 11
HIV Prevention: Implementing Proven Prevention Interventions to Control the Global Epidemic by Chris Collins, Todd Summers, and Tom Coates 441
Chapter 12
The Immunobiology of HIV -1 Infection by Norman L. Letvin 459
Chapter 13
HIV Vaccines 2000: Prospects and Challenges by Spyros A. Kalams and Bruce D. Walker 481
Index 511

A propos de l'auteur

Emilio A. Emini is the Vice President of Vaccine and Antiviral Research at the Merck Research Laboratories. There he led the biological basic research team that developed indinavir, one of the first HIV protease inhibitors, as well as the team involved in the initial discovery of efavirenz, another of the highly active therapeutic agents used to treat of HIV infection. Over the past few years, Dr. Emini has worked toward the development of an HIV vaccine. He holds a Ph.D. in virology from Cornell University's Graduate School of Medical Sciences.

Résumé

Provides an overview of the diverse areas that constitute HIV research. Each chapter is a comprehensive presentation of one area of AIDS research - including work on the virus life cycle, epidemiology, genetics, protease and reverse transcriptase inhibitors, receptor and co-receptor interactions, therapeutic targets, clinical treatment, and more.

Texte suppl.

"A superb and comprehensive volume that summarizes all that is taking place in HIV research at the present time. . . . [T]he leading comprehensive treatise on HIV research."---Pascal James Imperato, Journal of Community Health

Détails du produit

• Auteurs: Emilio Emini, Emilio A. Emini
• Collaboration: Emilio Emini (Editeur), Emilio A. Emini (Editeur), Emini Emilio A. (Editeur)
• Edition: Princeton University Press
• Langues: Anglais
• Format d'édition: Livre Relié
• Sortie: 27.01.2002
• EAN: 9780691004549
• ISBN: 978-0-691-00454-9
• Pages: 544
• Catégories: Sciences naturelles, médecine, informatique, technique > Médecine > Général; MEDICAL / AIDS & HIV, HIV / AIDS, Medicine: HIV/AIDS, retroviral diseases