Chemical and Structural Approaches to Rational Drug Design

This book is the first to provide both a broad overview of the current methodologies being applied to drug design and in-depth analyses of progress in specific fields. It details state-of-the-art approaches to pharmaceutical development currently used by some of the world's foremost laboratories. The book features contributors from a variety of fields, new techniques, previously unpublished data, and extensive reference lists.

Table des matières

Section I: Chemical Approaches to Rational Drug Design 1. Design, Synthesis and Antitumor Activity of an Inhibitor of Ribonucleotide Reductase 2. The Development of Human Immunodeficiency Virus Type 1 Reverse Transcriptase Inhibitors 3. The Development of Potent Angiotensin II Receptor Antagonists Using a Novel Peptide Pharmacophore Model 4. Endothelin Structure and Development of Receptor Antagonists 5. Molecular Targeting Chemistry in Rational Drug Design Section II: Structural Approaches to Rational Drug Design 6. The Role of X-Ray Crystallography in Structure-Based Rational Drug Design 7. Biocomputational Approaches to Protein-Based Drug Design 8. Architecture and Design of Zinc Protein-Ligand Complexes 9. Design of Immunomodulatory Peptides Based on Active Site Structures

A propos de l'auteur

Weiner\, David B.; Williams\, William V.

Résumé

This book deals with predominantly synthetic chemical approaches to drug design and explores the use of structure-activity relationships in the design of novel inhibitors of ribonucleotide reductase. It describes the application of the tools of structural biology to pharmaceutical development.

Détails du produit

• Auteurs: James McCarthy
• Collaboration: David B. Weiner (Editeur), Weiner David B. (Editeur), William B. Williams (Editeur), William V. Williams (Editeur), Williams William V. (Editeur), Mannfred A. Hollinger (Editeur de la série)
• Edition: Taylor and Francis
• Langues: Anglais
• Format d'édition: Livre Relié
• Sortie: 28.11.1994
• EAN: 9780849378188
• ISBN: 978-0-8493-7818-8
• Pages: 290
• Poids: 680 g
• Illustrations: schwarz-weiss Illustrationen, Raster,schwarz-weiss, Tabellen, schwarz-weiss
• Thème: Handbooks in Pharmacology and Toxicology
• Catégories: Sciences naturelles, médecine, informatique, technique > Médecine > Général; MEDICAL / Pharmacology, Pharmacology, Pharmaceutical technology, Pharmaceutical chemistry and technology, TECHNOLOGY & ENGINEERING / Pharmaceutical