Fr. 79.00

Green Chemistry: Novel Organocatalysts for Asymmetric Michael Addition - From Inception to Application: Developing Organocatalyts for Asymmetric Michael Addition by Enamine & Imminum Pathways

Anglais · Livre de poche

Expédition généralement dans un délai de 2 à 3 semaines (titre imprimé sur commande)

Description

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The development of green catalysts (organocatalysts) for fundamental carbon-carbon bond forming reactions is challenging. The organocatalytic Michael addition of ketones to nitroalkenes is of special interest as it generates two contiguous stereocenters and the products (Gamma- nitro ketones) are useful intermediates. This reaction can be efficiently catalyzed by pyrrolidine-based chiral, secondary diamines and triamines. The use of a protic acid in conjunction with the amine catalyst is beneficial and the Michael addition products (syn diastereomers) are obtained with excellent enantioselectivities (up to 99% ee) and diastereoselectivity (up to 50:1 dr) for cyclic ketones and nitroalkenes derived from aromatic aldehydes. The effect of changes in the catalyst and protic acid structure, variation of catalyst/protic acid combinations and effect of structural changes in the ketone and nitroalkenes are discussed. The application of the chiral triamines in Michael reactions involving iminium ion intermediates has been examined. The attempted syntheses of pyrrolidine-based organocatalysts with guanidine-containing side chains as well as catalysts based on the camphor scaffold are presented.

A propos de l'auteur










Dr. Keyur Pandya is a seasoned technocrat with more than 15 years of hands-on experience developing sustainable innovation chemicals/processes from a dawn to commercialization. He received his PhD in Chemistry from University of Alberta, Canada and published several scientific papers. In 2017 he earned the Best & Brightest Young Professional Award.

Détails du produit

Auteurs Keyur Pandya
Edition LAP Lambert Academic Publishing
 
Langues Anglais
Format d'édition Livre de poche
Sortie 30.06.2019
 
EAN 9786200093202
ISBN 9786200093202
Pages 144
Dimensions 150 mm x 220 mm x 8 mm
Poids 233 g
Catégories Littérature spécialisée > Nature, technique > Sciences naturelles
Sciences naturelles, médecine, informatique, technique > Chimie

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