Fr. 189.00

Next Generation Antibody Drug Conjugates (ADCs) and Immunotoxins

Anglais · Livre de poche

Expédition généralement dans un délai de 6 à 7 semaines

Description

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This book describes the newest developments in antibody drug conjugates and immunotoxins, paving their way to clinical application. Lessons learned from the current state of the art are used to further improve our understanding of their mechanisms of action and off target activities.

The book introduces scientists to all of the prerequisites that must be properly addressed, including identification of the right target, specific traits of target binding antibodies, proper selection of the toxic payload, internalization induced by binding, and next generation conjugation and linker technologies. These knowledge-based, revolutionary new drug principles will form the cornerstone of the future standard of care and will lead to major advances in application, as well as improved quality of life and patient survival rates. This book will be of interest to biotech companies and researchers working in the fields of immunology, pharmacology, and oncology.

Table des matières

Chemical Assembly of Antibody-Drug Conjugates.- Pre-clinical evaluation of ADCs delivering highly potent pyrrolobenzodiazepine (PBD) dimers.- Stable and homogeneous drug conjugation by sequential bis-alkylation at disulfide bonds using bis-sulfone reagents.- Calicheamicin antibody-drug conjugates for liquid- and solid tumor indications.- Enzyme-based strategies to generate site-specifically conjugated Antibody Drug Conjugates.- Substance P - Saporin for the Treatment of Intractable Pain.- Recombinant immunotoxins for Chronic Inflammatory Disease.- BL22: A milestone in targeting CD22.

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Résumé

This book describes the newest developments in antibody drug conjugates and immunotoxins, paving their way to clinical application. Lessons learned from the current state of the art are used to further improve our understanding of their mechanisms of action and off target activities.

The book introduces scientists to all of the prerequisites that must be properly addressed, including identification of the right target, specific traits of target binding antibodies, proper selection of the toxic payload, internalization induced by binding, and next generation conjugation and linker technologies. These knowledge-based, revolutionary new drug principles will form the cornerstone of the future standard of care and will lead to major advances in application, as well as improved quality of life and patient survival rates. This book will be of interest to biotech companies and researchers working in the fields of immunology, pharmacology, and oncology.

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Détails du produit

Collaboration Barth (Editeur), Barth (Editeur), Stefan Barth (Editeur), Ul Grawunder (Editeur), Ulf Grawunder (Editeur)
Edition Springer, Berlin
 
Langues Anglais
Format d'édition Livre de poche
Sortie 01.01.2018
 
EAN 9783319836096
ISBN 978-3-31-983609-6
Pages 181
Dimensions 155 mm x 10 mm x 235 mm
Poids 308 g
Illustrations XI, 181 p. 57 illus., 39 illus. in color.
Thèmes Milestones in Drug Therapy
Milestones in Drug Therapy
Catégories Sciences naturelles, médecine, informatique, technique > Médecine > Pharmacie

Onkologie, B, Krankheiten und Störungen, Immunology, INTERNAL MEDICINE, Oncology, Pharmacology, Health Sciences, Biomedical and Life Sciences, Cancer Research, Biomedical Research, pharmacotherapy, Pharmacology/Toxicology, Therapy and therapeutics, Diseases and disorders, Antibodies

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