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Table des matières
INTRODUCTION. THE CONCEPT OF CONTROLLED DRUG DELIVERY AND DRUG TARGETING. INTERACTION OF I.V. ADMINISTERED CARRIERS WITH BLOOD COMPONENTS AND THE RETICULOENDOTHELIAL SYSTEM. IN VIVO FATE OF I.V. ADMINISTERED DRUG CARRIERS. BIODEGRADABLE CARRIERS FOR DRUG DELIVERY. LOCALIZATION OF CARRIERS IN THE TARGET TISSUE. TARGETING WITH I.V. ADMINISTERED CARRIERS-POTENTIALS AND LIMITATIONS. MODIFICATION OF DRUG CARRIERS. SURFACE MODIFICATION BY POLYMER ADSORPTION. COATING WITH POLOXAMER AND POLOXAMINE POLYMERS. COATING WITH POLYOXYLATED ALKYL PHENOLS. COATING WITH PHOSPHOLIPIDS. COATING WITH MISCELLANEOUS ETHOXYLATED COMPOUNDS. GAMMA-IRRADIATION AND PLASMA ETCHING. Effects of Irradiation and Plasma Etching on Polymers. Materials and Methods. Treatment of Polyhydroxybutyrate (PHB). Summary. CHARACTERIZATION OF CARRIERS. MODEL CARRIERS. SIZE DETERMINATIONS. Importance of Size for Drug Carriers. Methods and Experimental. Results of Size Determinations. CHARGE DETERMINATIONS. Influence of Carrier Charge on In Vivo Fate. Laser Doppler Anemometry (LDA). Amplitude Weighted Phase Structuration (AWPS). SURFACE HYDROPHOBICITY. Importance of Surface Properties for Drug Carriers. Rose Bengal Binding Methods. Hydrophobic Interaction Chromatography (HIC). Aqueous Two Phase Partitioning. CHEMICAL ANALYSIS OF THE CARRIER SURFACE. Static Secondary Ion Mass Spectrometry (SSIMS). SSIMS Analysis of Carriers. DETERMINATION OF CFT OF COATED CARRIERS. Theoretical and Experimental. Results of CFT Determination. Summary. NON-BIODEGRADABLE MODEL CARRIERS. PROBLEMS ASSOCIATED WITH THE USE OF MODEL CARRIERS. PRODUCTION OF POLYSTYRENE MODEL PARTICLES. Materials. Material Purification. Particle Production. INFLUENCE OF PRODUCTION PARAMETERS ON LATEX SIZE. INCORPORATION OF COLLOIDAL GOLD IN LATEX MODEL CARRIERS. PRODUCTION OF LATEX PARTICLES OF A MEAN SIZE BELOW 100 nm. SUMMARY. BIODEGRADABLE POLYMERIC CARRIERS. BIODEGRADABLE POLYMERS FOR DRUG CARRIERS. MATERIALS AND METHODS. PRODUCTION OF CARRIERS. Emulsifi
A propos de l'auteur
Rainer H. Muller
Résumé
Deals with the physico-chemical characterization of colloidal drug delivery systems and the influence of these parameters upon in vitro cell uptake and in vivo tissue distribution. This book discusses several different methods and their effect on surface characterization.
