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The future is now--this groundbreaking textbook illustrates how biotechnology has radically changed the way we think about health care
Biotechnology is delivering not only new products to diagnose, prevent, and treat human disease but entirely new approaches to a wide range of difficult biomedical challenges. Because of advances in biotechnology, hundreds of new therapeutic agents, diagnostic tests, and vaccines have been developed and are available in the marketplace.
In this jargon-free, easy-to-read textbook, the authors demystify the discipline of medical biotechnology and present a roadmap that provides a fundamental understanding of the wide-ranging approaches pursued by scientists to diagnose, prevent, and treat medical conditions.
Medical Biotechnology is written to educate premed and medical students, dental students, pharmacists, optometrists, nurses, nutritionists, genetic counselors, hospital administrators, and individuals who are stakeholders in the understanding and advancement of biotechnology and its impact on the practice of modern medicine.
Hardcover, 700 pages, full-color illustrations throughout, glossary, index.
Table des matières
Preface
About the Authors
Section I: The Biology behind the Technology
Chapter 1: Fundamental Technologies
Molecular Cloning
Genomic Libraries
Amplification of DNA Using PCR
DNA Sequencing Technologies
Sequencing Whole Genomes
Genomics
Chapter 2: Fundamental Concepts in Immunology
The Immune Response
Functions of the Immune System
Cells of the Immune System: Cell-Mediated
Tissues of the Immune System
Humoral Immunity
Types of Antibodies: Applications
Immunological Techniques
Chapter 3: The Genetic Basis of Disease
Chromosomal Disorders and Gene Mapping
Single-Gene Disorders
Polygenic Disorders and Gene Clustering
Mitochondrial Disorders
Chapter 4: Immune Pathogenesis
Models of Immune System Lesions
Inflammation and Immune Hypersensitivity
Immunodeficiency Disorders and Defects in Development of the Immune System
Chapter 5: Microbial Pathogenesis
Introduction
Bacterial Infections
Viral Infections
Section II: Production of Therapeutic Agents
Chapter 6: Modulation of Gene Expression
Manipulating Gene Expression in Prokaryotes
Heterologous Protein Production in Eukaryotic Cells
Directed Mutagenesis
Chapter 7: Genetic Engineering of Plants
Plant Transformation with the Ti Plasmid of A. tumefaciens
Physical Transfer of Genes to Plants
Chloroplast Engineering
Transient Gene Expression
Molecular Pharming
Edible Vaccines
Section III: Diagnosing and Treating Human Disease
Chapter 8: Molecular Diagnostics
Immunological Approaches to Detect Protein Biomarkers of Disease
DNA-Based Approaches to Disease Diagnosis
Detecting RNA Signatures of Disease
Chapter 9: Protein Therapeutics
Pharmaceuticals
Recombinant Antibodies
Enzymes
Lactic Acid Bacteria
Chapter 10: Nucleic Acid Therapeutic Agents and Human Gene Therapy
Treating Genetic and Nongenetic Disorders
Targeting Specific mRNAs and DNAs
Viral Delivery Systems
Nonviral Nucleic Acid Delivery Systems
Gene Therapy
Chapter 11: Vaccines
Vaccination: Overview
Subunit Vaccines
Peptide Vaccines
Dendritic Cell Vaccines
DNA Vaccines
Attenuated Vaccines
Vector Vaccines
Adjuvants
Systems Biology and Evaluation of Vaccines
Chapter 12: Societal Issues
Safety and Ethical Issues
Patenting Biotechnology
Economic Issues
Glossary
Index
