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This book describes important developments and emerging trends in experimental and clinical cancer gene therapy. It reflects the tremendous advances made over recent years with respect to immunogenes, suicide genes and gene correction therapies, as well as in gene suppression and miRNA therapies. Many of the described strategies focus on the generation of more efficient and specific means of attack at known and novel cellular targets associated with tumor development and progression. The book also details parallel improvements in vector design, vector delivery, and therapeutic efficacy. It offers readers a stimulating, broad overview of advances in the field, linking experimental strategies to their clinical applications.
Table des matières
Cancer Gene therapy trials worldwide.- Viral vectors for cancer gene therapy.- Nonviral vectors for cancer gene therapy.- Delivery systems for cancer gene therapy.- Targeted vectors for cancer gene therapy.- Current strategies for cancer suicide gene therapy.- Stem cell guided gene therapy for cancer.- Gene replacement therapy to treat cancer.- miRNA for cancer gene therapy.- Gene suppression gene therapy for cancer.- Recent developments in oncolytic virus therapy.- DNA vaccination for cancer therapy.- mRNA based cancer vaccines.- Engineered T-cells to treat cancer.- Gene therapy for overcoming drug resistance.
Résumé
This book describes important developments and emerging trends in experimental and clinical cancer gene therapy. It reflects the tremendous advances made over recent years with respect to immunogenes, suicide genes and gene correction therapies, as well as in gene suppression and miRNA therapies. Many of the described strategies focus on the generation of more efficient and specific means of attack at known and novel cellular targets associated with tumor development and progression. The book also details parallel improvements in vector design, vector delivery, and therapeutic efficacy. It offers readers a stimulating, broad overview of advances in the field, linking experimental strategies to their clinical applications.
