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This second edition provides updated and expanded chapters that critically address the issues or rodent stroke modeling, from choosing the model and outcome measures, designing the experiment, conducting and analyzing it, to reporting it in a scientific publication. Rodent Models of Stroke, Second Edition aims to help its readers understand the limitations and the opportunities of modeling stroke in rodents and enable them to conduct experiments which will not only improve our understanding of the pathophysiology of this devastating disorder but also serve as the basis for developing new highly effective treatments. Written for the popular Neuromethods series, chapters include the kind of detail and key implementation advice that ensures successful results in the laboratory.
Authoritative and practical, Rodent Models of Stroke, Second Edition provides authoritative reviews of the most commonly used, well-honed approachesin the field today.
Table des matières
From Bedside to Bench: How Clinical Reality Should Instruct Stroke Modeling.- How to Avoid Bumping into the Translational Roadblock.- Modeling Focal Cerebral Ischemia in Rodents: Introduction and Overview.- Focal Cerebral Ischemia in the Mouse and Rat by Intraluminal Suture.- Focal Ischemia Models: Middle Cerebral Artery Occlusion Induced by Electrocoagulation, Occluding devices and Endothelin-1.- Mouse Model of in situ Thromboembolic Stroke and Reperfusion.- Photochemical Models of Focal Brain Ischemia.- Housing in an Enriched Environment - A Tool to Study Functional Recovery after Experimental Stroke.- Modeling Risk Factors and Confounding Effects in Stroke.- Effect of Anesthesia in Stroke Models.- Non-invasive Brain Imaging in Small Animal Stroke Models: MRI, PET and SPECT.- Non-invasive Optical Imaging in Rodent Models of Stroke .- Behavioral Testing in Rodent Models of Stroke, Part I.- Behavioral Testing in Rodent Models of Stroke -Part II.- Combining Classical Comprehensive With Ethological Based, High Throughput Automated Behavioral Phenotyping for Rodent Models of Stroke.- Histology and Infarct Volume Determination in Rodent Models of Stroke.- Ethics of Modeling of Cerebral Ischemia in Small Animals.- Quality Control and Standard Operating Procedures.- Statistics in Experimental Stroke Research: From Sample Size Calculation to Data Description and Significance Testing.- Complexities, Confounders, and Challenges in Experimental Stroke Research: A Checklist for Researchers and Reviewers.
Résumé
This second edition provides updated and expanded chapters that critically address the issues or rodent stroke modeling, from choosing the model and outcome measures, designing the experiment, conducting and analyzing it, to reporting it in a scientific publication. Rodent Models of Stroke, Second Edition aims to help its readers understand the limitations and the opportunities of modeling stroke in rodents and enable them to conduct experiments which will not only improve our understanding of the pathophysiology of this devastating disorder but also serve as the basis for developing new highly effective treatments. Written for the popular Neuromethods series, chapters include the kind of detail and key implementation advice that ensures successful results in the laboratory.
Authoritative and practical, Rodent Models of Stroke, Second Edition provides authoritative reviews of the most commonly used, well-honed approachesin the field today.
