Progress in the Chemistry of Organic Natural Products 102

The first contribution reviews the phytochemical, chemical,and biological literature on members of the ingenane class of diterpenoids fromtheir first isolation in 1968 through 2015, highlighting unresolved issues bothcommon to phorboids and specific to ingenol derivatives. The biogenesis of ingenol is discussed in thelight of the Jakupovic proposal of a dissection between the formation of the macrocyclicEuphorbia diterpenoids and the phorboids,and the clinical development of ingenol mebutate is chronicled in the light ofits "reverse-pharmacology" focus.
The second contributionoffers a comprehensive view of the chemical wealth and the taxonomic problemscurrently impeding chemical and biological investigations of the genus Laurencia. It addresses the botanical description and the growth andpopulation dynamics of the genus, as well as its chemical diversity and ecologicalrelations; the secondary metabolites as well as their sources of isolation; and finally the biological activity.

Table des matières

The Laurencia paradox:an endless source of chemodiversity. - Ingenane Dipernoids.

Résumé

The first contribution reviews the phytochemical, chemical,
and biological literature on members of the ingenane class of diterpenoids from
their first isolation in 1968 through 2015, highlighting unresolved issues both
common to phorboids and specific to ingenol derivatives. The biogenesis of ingenol is discussed in the
light of the Jakupovic proposal of a dissection between the formation of the macrocyclic
Euphorbia diterpenoids and the phorboids,
and the clinical development of ingenol mebutate is chronicled in the light of
its “reverse-pharmacology” focus.
The second contribution
offers a comprehensive view of the chemical wealth and the taxonomic problems
currently impeding chemical and biological investigations of the genus Laurencia. It addresses the botanical description and the growth and
population dynamics of the genus, as well as its chemical diversity and ecological
relations; the secondary metabolites as well as their sources of isolation; and finally the biological activity.

Détails du produit

• Collaboration: Hein Falk (Editeur), Heinz Falk (Editeur), Simon Gibbons (Editeur), Simon Gibbons et al (Editeur), A. Douglas Kinghorn (Editeur), Jun'ichi Kobayashi (Editeur)
• Edition: Springer, Berlin
• Langues: Anglais
• Format d'édition: Livre Relié
• Sortie: 01.01.2016
• EAN: 9783319331706
• ISBN: 978-3-31-933170-6
• Pages: 252
• Dimensions: 169 mm x 245 mm x 18 mm
• Poids: 550 g
• Illustrations: V, 252 p. 190 illus., 10 illus. in color.
• Thèmes: Progress in the Chemistry of Organic Natural Products; Progress in the Chemistry of Organic Natural Products
• Catégories: Sciences naturelles, médecine, informatique, technique > Chimie > Chimie organique; B, Medizinische Chemie, Pharmazeutische Chemie, ORGANIC CHEMISTRY, biochemistry, Chemistry and Materials Science, Medical Biochemistry, MEDICINAL CHEMISTRY