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Informationen zum Autor Jie Jack Li is an Associate Professor of chemistry at the University of San Francisco. Previously, he was a chemist at Bristol-Myers Squibb Company. He has authored or edited several books published by Wiley, including Drug Discovery: Practices, Processes, and Perspectives , Heterocyclic Chemistry in Drug Discovery , Name Reactions in Heterocyclic Chemistry , Name Reactions for Functional Group Transformations , Contemporary Drug Synthesis , The Art of Drug Synthesis , and Modern Drug Synthesis . Douglas Johnson is an Associate Research Fellow and head of Chemical Biology in the Neuroscience Medicinal Chemistry group at Pfizer Worldwide Research and Development. He is a co-author on more than 70 publications and patents and is a co-author of the book Contemporary Drug Synthesis and is an editor of The Art of Drug Synthesis , and Modern Drug Synthesis (all published by Wiley). Klappentext This set presents the authoritative and acclaimed Drug Synthesis books edited by Jie Jack Li and Douglas Johnson: Contemporary Drug Synthesis , The Art of Drug Synthesis , Modern Drug Synthesis, and Innovative Drug Synthesis . Zusammenfassung This set presents the authoritative and acclaimed Drug Synthesis books edited by Jie Jack Li and Douglas Johnson: Contemporary Drug Synthesis! The Art of Drug Synthesis! Modern Drug Synthesis! and Innovative Drug Synthesis. Inhaltsverzeichnis Contemporary Drug Synthesis Preface v Trade Names and Their Corresponding USANs xi Acronyms and Abbreviations xiii Chapter 1. Antithrombotics: Ticlopidine (Ticlid) and Clopidogrel (Plavix) 1 Chapter 2. Anti-inflammatory Cyclooxygenase-2 Selective Inhibitors: Celecoxib (Celebrex) and Rofecoxib (Vioxx) 11 Chapter 3. H+/K+ -ATPase Inhibitors: Esomeprazole (Nexium) 21 Chapter 4. Protein-tyrosine Kinase Inhibitors: Imatnib (Gleevec) and Gefitinib (Iressa) 29 Chapter 5. Non-sedating Antihistamines 39 Chapter 6. Cosmeceuticals: Istretinoin (Accutane), Tazarotene (Tazorac), Minoxidil (Rogaine), and Finasteride (Propecia) 55 Chapter 7. Antibacterials: Ciprofloxacin (Cipro) and Linezolid (Zyvox) 75 Chapter 8. Atypical Antupsychotics 89 Chapter 9. Atovastatin Calcium (Lipitor) 113 Chapter 10. Antidepressants 125 Chapter 11. Anti-obesity: Orlistat (Xenical) 149 Chapter 12. Triptans for Migrane 161 Chapter 13. PDE 5 Inhibitors for Erectile Dysfunction: Sildenafil (Viagra), Vardenafil (Levitra), and Tadalafil (Cialis) 189 Chapter 14. Antiasthmatics 201 Index 214 The Art of Drug Synthesis 1 THE ROLE OF MEDICINAL CHEMISTRY IN DRUG DISCOVERY 1 John A. Lowe, III 2 PROCESS RESEARCH: HOW MUCH? HOW SOON? 11 Neal G. Anderson 3 AROMATASE INHIBITORS FOR BREAST CANCER: EXEMESTANE (AROMASIN), ANASTROZOLE (ARIMIDEX), AND LETROZOLE (FEMARA) 31 Jie Jack Li 4 QUINOLONE ANTIBIOTICS: LEVOFLOXACIN (LEVAQUIN), MOXIFLOXACIN (AVELOX), GEMIFLOXACIN (FACTIVE), AND GARENOXACIN (T-3811) 39 Chris Limberakis 5 TRIAZOLE ANTIFUNGALS: ITRACONAZOLE (SPORANOX), FLUCONAZOLE (DIFLUCAN), VORICONAZOLE (VFEND), AND FOSFLUCONAZOLE (PRODIF) 71 Andrew S. Bell 6 NON-NUCLEOSIDE HIV REVERSE TRANSCRIPTASE INHIBITORS 83 Arthur Harms 7 NEURAMINIDASE INHIBITORS FOR INFLUENZA: OSELTAMIVIR PHOSPHATE (TAMIFLU) AND ZANAMIVIR (RELENZA) 95 Douglas S. Johnson and Jie Jack Li 8 PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR (PPAR) AGONISTS FOR TYPE 2 DIABETES 117 Jin Li 9 ANGIOTENSIN AT1 ANTAGONISTS FOR HYPERTENSION 129 Larry Yet 10 LEADING ACE INHIBITORS FOR HYPERTENSION 143 Victor J. Cee and Edward J. Olhava 11...
