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Transforming growth factor-beta (TGF-beta) is a secreted polypeptide with multifunctional properties manifested during embryonic development, adult organ physiology, and pathobiology of major diseases, including cancer and fibrotic and cardiovascular diseases. The signaling pathway of TGF-beta now is rather well understood. Continuing revelations in the mechanisms of action of TGF-beta provide specific mechanistic examples of how human cells lose their controlled function and behave wrongly during the development of diverse diseases. Equally important, however, is the current promise of exploiting the TGF-beta pathway in combating human disease. This book comprehensively covers major areas of human disease where the involvement of TGF-beta is firmly established. Simultaneously, the book highlights major gaps in knowledge and the future directions of research that can benefit human medical science. The core set of diseases where TGF-beta action is well documented and are included in the book are cancer and cardiovascular and fibrotic disorders. The central aim of the book is to stimulate young scientists to enter the prolific TGF-beta field and find new solutions to the problems remaining in this area of study. For this purpose the book provides authoritative educational chapters that furnish a good introduction to the field for young doctoral students, postdocs, and clinical fellows. The book also serves as a valuable reference for the aficionados in the field, who can find accessible and well-illustrated material for their teaching and lecturing activities, via which the importance of TGF-beta biology is disseminated to the world of science and to the public.
Table des matières
Part I Introduction.- 1 Transforming Growth Factor-beta Signaling.- 2 TGF-beta Signaling in Stem Cell Fate Determination.- 3 Emerging Roles of TGF-beta Co-receptors in Human Disease.- Part II Cancer, Fibrosis, and Inflammation.- 4 TGF-beta in Cancer Stem Cells.- 5 TGF-beta as Tumor Suppressor: In Vitro Mechanistic Aspects of Growth Inhibition.- 6 TGF-beta as Tumor Suppressor: Lessons from Mouse Models.- 7 The Multifunctional Roles of TGF-beta in Navigating the Metastatic Cascade.- 8 TGF-beta Signaling in Leukemogenesis.- 9 TGF-beta in Skin Cancer and Fibrosis.- 10 The Role of TGF-beta in Cutaneous Melanoma Biology.- 11 The Transforming Growth Factor-Beta (TGF-beta) in Liver Fibrosis.- 12 TGF-beta and Inhibitory Smads in Inflammation.- Part III Cardiovascular Diseases.- 13 TGF-beta and Cardiovascular Disorders.- 14 TGF-beta Signaling in Physiological and Pathological Angiogenesis.- 15 TGF-beta Signaling Pathway and MicroRNAs in Cardiovascular Disease.- Part IV Other Diseases.- 16 TGF-beta and Genetic Skeletal Diseases.- 17 TGF-beta in Brain Disorders.- 18 TGF-beta and Metabolic Homeostasis.- Part V Disease Prognosis and Therapy. 19 Targeting Pro-Angiogenic TGF-beta Signaling in the Tumor Microenvironment.
Résumé
Transforming growth factor-β (TGF-β) is a secreted polypeptide with multifunctional properties manifested during embryonic development, adult organ physiology, and pathobiology of major diseases, including cancer and fibrotic and cardiovascular diseases. The signaling pathway of TGF-β now is rather well understood. Continuing revelations in the mechanisms of action of TGF-β provide specific mechanistic examples of how human cells lose their controlled function and behave wrongly during the development of diverse diseases. Equally important, however, is the current promise of exploiting the TGF-β pathway in combating human disease. This book comprehensively covers major areas of human disease where the involvement of TGF-β is firmly established. Simultaneously, the book highlights major gaps in knowledge and the future directions of research that can benefit human medical science. The core set of diseases where TGF-β action is well documented and are included in the book are cancer and cardiovascular and fibrotic disorders. The central aim of the book is to stimulate young scientists to enter the prolific TGF-β field and find new solutions to the problems remaining in this area of study. For this purpose the book provides authoritative educational chapters that furnish a good introduction to the field for young doctoral students, postdocs, and clinical fellows. The book also serves as a valuable reference for the aficionados in the field, who can find accessible and well-illustrated material for their teaching and lecturing activities, via which the importance of TGF-β biology is disseminated to the world of science and to the public.
