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Here, the whole range of the functionalization of CH-bonds is presented for the first time in one handbook, with the focus throughout on topicality and practicability. Topics span modern catalysts for Friedel-Crafts type reactions to transition metal catalysts for the oxofunctionalization, via new methods for radicalic halogenation to domino processes by catalytic ortho metalation.Renowned for his research as well as for his excellent articles and reviews, Gerald Dyker provides in these two volumes reliable and typical experimental procedures, thus lending the book great practical value.
Table des matières
INTRODUCTION AND BACKGROUNDCH ACTIVATION AT SP-HYBRIDIZED CARBON ATOMSAt terminal alkynes- base-induced or catalyzed addition of terminal alkynes to elektrophiles- Sonogashira coupling reaction- Glaser coupling reactionAt HCN- hydrocyanation of alkenes and alkynes- enantioselective addition of HCN to carbonyl compoundsCH ACTIVATION AT SP2-HYBRIDIZED CARBON ATOMSAt arenes- CO-bond formation by oxidation- by stoichiometric oxidants- by enzymes- supported by artificial transition metal catalysts- towards industrial application: addition to unfunctionalized olefines- Rh-catalyzed carbonylation- Rh-catalyzed and Pt-catalyzed silylation- ortho-selective alkylation of arenes- DOM reaction- intermolecular Pd-catalyzed arylations- Pd-catalyzed arylations via palladacycles- oxidative vinylation: Pd-catalyzed in comparison to Rh-catalyzed processesAt alkenes- via cyclometallated Ru-complexes (or: Ru-catalyzed activation of alkenyl esters)- via cyclometallated Rh-complexes- Heck reaction- via cyclopalladation- Wacker oxidationAt aldehydes- via cyclopalladation- via cyclometallation with rhodium catalysts- inter- and intramolecular (enantioselective) hydroacylationCH ACTIVATION AT SP3-HYBRIDIZED CARBON ATOMSAt functionalized alkanes- in allylic and benzylic position- via palladacycles- via cyclometallated complexes- in a-position of nitriles- asymmetric aldol reactions and related reactions- oxidative free-radical Cyclizations with b-dicarbonyl compounds- aerobic oxidation of alcoholsAt unfunctionalized alkanes- CO-bond formation by oxidation- radicalic halogenation- photochemical processes- heterogenic catalysis by silica supported hydrido tantalum- Pd-catalyzed carboxylation- olefines by transition metal catalyzed dehydrogenation
A propos de l'auteur
Gerald Dyker was born in 1960. He studied chemistry at Dortmund University where he received his doctorate in 1988 for a thesis on ortho-quinonoid hetarenes. After postdoctoral research on ruthenium catalysis at Stanford University, he worked as a research chemist at Bayer AG in the field of veterinary pharmaceuticals. A Liebig fellowship enabled the completion of his habilitation on palladium catalyzed domino processes in 1994 at the Technical University of Braunschweig. Between 1995 and 1999 he was Professor for Organometallic Chemistry at Duisburg University. Since 2000 he has been Professor for Organic Chemistry at Bochum University. In addition to transition metal catalysis his current research interests include the synthesis of various complex targets, such as ligands with multiple coordination sites and a "nanodimensional baseball glove" for the complexation of metallic nanoparticles.
Résumé
Here, the whole range of the functionalization of CH-bonds is presented for the first time in one handbook, with the focus throughout on topicality and practicability. Topics span modern catalysts for Friedel-Crafts type reactions to transition metal catalysts for the oxofunctionalization, via new methods for radicalic halogenation to domino processes by catalytic ortho metalation.
Renowned for his research as well as for his excellent articles and reviews, Gerald Dyker provides in these two volumes reliable and typical experimental procedures, thus lending the book great practical value.
Commentaire
"...bietet dieses Handbuch sehr viele Hintergrundinformationen sowie Verweise auf aktuelle Arbeiten über wichtige Reaktionen und "hot topics" in der organischen Synthese. Die beiden Bände sollten jedem zugänglich sein, der sich mit organischen Synthesen beschäftigt."Angewandte Chemie
