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Zusatztext " ... an excellent and timely book ... one that will prove helpful to many a protein biochemist ... Protein Protein Recognition will serve as an exceptional sourcebook for its subject for some time to come." Cell Klappentext In the light of new information from the genome sequencing projects and the increase in structural information! this book brings together concepts and systems pertaining to protein-protein interactions in an examination of how and why proteins form complexes with each other. The emphasis ofthe text is on heteromeric complexes and uses well-studied model systems to explain the processes of forming complexes. There is an introductory section on the kinetics! thermodynamics! analysis! and classification of protein-protein interactions. Electron transfer proteins and integrin complexesrepresent weak affinity complexes. Anti-lysosomal antibodies! the MHC proteins and their interactions with T-cell receptors! and the protein interactions of eukaryotic signal transduction are the systems used to explain complexes with intermediate affinities. Throughout the book the common themesare the technologies which have had the greatest impact! how specificity is determined! how complexes are stabilized! and medical and industrial applications. Zusammenfassung Protein-protein recognition is a critical event controlling in a large number of cell processes and therefore is of interest to a large section of the biological community. The purpose of this book is to bring together important concepts and systems in a single volume. Kinetics and thermodynamics of protein-protein interactions; Analysis and classification of protein-protein interactions from a structural perspective; Protein-protein complexes formed by electron transfer proteins; Molecular basis of integrin-dependent cell adhesion; Structure and energetics of anti-lysozyme antibodies; Proteins of the major histocompatibility complex and their interactions with T-cell receptors; Protein-protein interactions in eukaryotic signal transduction; Interaction of standard mechanism, canonical protein inhibitors with serine proteinases; Nuclease inhibitors...
