Hiv: Volume 2: Biochemistry, Molecular Biology, and Drug Discovery - A Practical Approach

Klappentext HIV Volume 2 explores the biochemistry and molecular biology of HIV. Methods for cloning and expressing most of the viral proteins are described as well as assays for studying enzyme function in vitro. It also includes a section on recent approaches to drug discovery. Contents: The HIV life cycle; Reverse transcriptase; Ribonulease H; Integrase; Protease; Expression of gag, envelope and other HIV antigens using Bacculovirus; Envelope expression and purification; HIV envelope glyocoprotein/CD4 interactions - studies using recombinant vaccinia virus vectors; RNA binding assays for the regulatory proteins tat and rev; Cellular and cell-free assays for tat; Cellular assays for rev; DNA binding proteins interacting with the viral LTR; Nef; Vpu; Vif; Cellular assays for antiviral drugs; Inhibition of HIV by ribozymes and antisense oligonucleotides; Gene therapy approaches to the inhibition of HIV Zusammenfassung AIDS is undeniably one of the most pressing medical emergencies of our era. This two-volume work summarizes all research efforts to date. The present volume describes studies of its biochemistry and molecular biology, providing clear guidelines for laboratory practice.

Détails du produit

• Auteurs: J. Karn, Jonathan Karn
• Collaboration: Jonathan Karn (Editeur), Jonathan (MRC Laboratory of Molecular Biology Karn (Editeur)
• Edition: Oxford University Press
• Langues: Anglais
• Format d'édition: Livre de poche
• Sortie: 09.11.1995
• EAN: 9780199634989
• ISBN: 978-0-19-963498-9
• Pages: 354
• Thème: Practical Approach Series
• Catégories: Livres de conseils > Santé; Sciences naturelles, médecine, informatique, technique > Biologie > Biochimie, biophysique