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Zusatztext ' an immense work of scholarship...There is very little of the subject that has been missed and not scrutinized' Acta Crystallographica Informationen zum Autor Professor Carmelo Giacovazzo, Professor of Mineralogy, Dipartemento Geomineralogico, Universitá di Bari, Via Orabona, 4 70125 Bari, Italy. Tel: 0039 80 5442590. Fax: 0039 80 5442591. Email: giacovazzo@area. ba.cnr.it Klappentext Direct methods are now used in a variety of cases: X-ray, neutron or electron data; single crystal and powder data; small molecules and macromolecules. While direct methods solved in practice the phase problem for small molecules, their application to macromolecules is recent and stillundergoing development. This book describes the fundamental methods; in particular it is shown how the methods can be optimized for powder, neutron or electron data, and how they can be integrated with isomorphous replacement, molecular replacement and anomalous dispersion techniques. Maximumentropy methods are also described and discussed. Sets of test structures are used throughout the various chapters to verify the mathematical techniques and to provide practical examples. This book offers both a comprehensive description of direct methods in crystallography and an invaluablereference tool. The first three chapters provide an introduction to the field, with sufficient material to constitute a university course. Subsequent chapters are aimed at graduate students and working crystallographers. Basic results are described and discussed in the main body of the text, whilethe appendices complement these with in depth mathematical details. The quoted literature is extremely wide and the interested reader can find suggestions for future work and further reading throughout the book. Zusammenfassung Direct Methods are the widely used techniques for solving the crystal structures of small molecules, with applications in macromolecular crystallography. This book offers a description of the field and a reference tool for scientists from undergraduate physics, chemistry, biochemistry, mineralogy students, and the professional crystallographer....
