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The book contains chapters written by leaders in the research on the structure and function of respiratory complex I. It will provide a concise and authoritative summary of the current knowledge on complex I of respiratory chains. This enzyme is central to energy metabolism and is implicated in many human neurodegenerative diseases, as well as in aging. Until recently it was poorly understood on a structural level, and this book will provide a timely reference resource. Such a book was not published previously. The last time a minireview series on complex I were published was in 2001, and since then complex I field changed quite dramatically.
Table des matières
Part I: Structure and mechanism of complex I. - 1. Structure of complex I. - 2. On the mechanism of the respiratory complex I. - 3. Iron-sulfur clusters in complex I. - 4. Current Topics of the Inhibitors of Mitochondrial Complex I. - 5. My Fifty Years Association with Complex I Study. - Part II: Evolution of complex I. - 6. The Evolutionary Relationship between Complex I and [NiFe]-hydrogenase. - 7. Recruitment of the antiporter module - a key event in complex I evolution. - Part III: Mutations in complex I subunits and medical implications. - 8. Characterization of Bacterial Complex I (NDH-1) by a Genetic Engineering Approach. - 9. Cellular consequences of mtDNA-encoded mutations in NADH:ubiquinone oxidoreductase. - Part IV: Subunit composition and assembly of mitochondrial complex I. - 10. The assembly of human complex I. - 11. Complexes I in the green lineage. -Part V: Supercomplexes in mitochondria. - 12. Supramolecular organization of the respiratory chain.
Résumé
The book contains chapters written by leaders in the research on the structure and function of respiratory complex I. It will provide a concise and authoritative summary of the current knowledge on complex I of respiratory chains. This enzyme is central to energy metabolism and is implicated in many human neurodegenerative diseases, as well as in aging. Until recently it was poorly understood on a structural level, and this book will provide a timely reference resource. Such a book was not published previously. The last time a minireview series on complex I were published was in 2001, and since then complex I field changed quite dramatically.
