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A panel of expert clinical researchers offer a practical guide to the key animal models used in vascular disease. These experts examine critical issues related to vascular disease and injury in five major areas: acute mechanical injury and vascular repair, arterial thrombosis, chronic atherosclerosis, vascular disease in transplanted vessels, and vascular disease in systemic and pulmonary arterial hypertension. Up-to-date and highly practical, Vascular Disease and Injury: Preclinical Studies provides a comprehensive review that not only illuminates the current status of cardiovascular research, but also offers vascular biologists and cardiologists a detailed how-to guide to the development of the many powerful new therapeutics now emerging.
Table des matières
I Acute Mechanical Injury and Vascular Repair.- 1 Mechanical Injury in Normal and Atherosclerotic Rabbit Iliac Arteries.- 2 The Porcine Model of Coronary Restenosis.- 3 Atherosclerotic Porcine Coronary Stent Model: Technical Methods for Preclinical Studies.- 4 Nonhuman Primate Models of Arterial Injury and Repair.- 5 Experimental Models of Arteriovenous Grafting.- 6 Wire Denudation and Ligation Models of the Mouse Carotid Artery.- 7 Endothelial Denudation and Arterial Dilation in the Mouse.- 8 Vascular Photochemical Injury in the Mouse.- 9 Mouse Model of Transluminal Femoral Artery Injury.- II Models of Arterial Thrombosis.- 10 A Murine Model of Arterial Injury and Thrombosis.- 11 Folts Cyclic Flow Animal Model for Studying In Vivo Platelet Activity and Platelet Interactions with Damaged Arterial Walls.- III Chronic Atherosclerotic Models.- 12 Mouse Models of Atherosclerosis.- 13 Rabbit Models of Atherosclerosis.- 14 Atherosclerosis in Nonhuman Primates.- IV Vascular Disease in Transplanted Vessels.- 15 Murine Carotid Loop Model of Transplant Vascular Disease.- 16 Murine Heterotopic Model of Transplant Arteriopathy.- 17 Hyperacute Vascular Rejection: Lessons from Pig-to-Primate Xenotransplantation.- V Vascular Disease in Models of Arterial Hypertension.- 18 Methods for Examining Cerebrovascular Disease in Experimental Models of Hypertension.- 19 Monocrotaline-Induced Pulmonary Hypertension in Rats.- 20 Chronic Pulmonary Hypertension in the Hypoxic Rat and in the Sheep Following Continuous Air Embolization.- VI Animal Care and Tissue Processing.- 21 Veterinary Issues and Anesthesia Options.- 22 Histological and Immunohistochemical Methods for Vascular Animal Model Studies.
Résumé
These experts examine critical issues related to vascular disease and injury in five major areas: acute mechanical injury and vascular repair, arterial thrombosis, chronic atherosclerosis, vascular disease in transplanted vessels, and vascular disease in systemic and pulmonary arterial hypertension.
