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In recent years remarkable progress has been accomplished with respect to our knowledge about bacterial protein toxins. This refers especially to structural aspects of protein toxins but also holds true for genetics, molecular biology and biochemical mechanisms underlying the action of toxins. This volume covers the very current and exciting aspects of up-to-date bacterial toxicology and comprehensively reviews the most important bacterial protein toxins such as the intracellular acting toxins which exhibit enzyme activity, as well as those toxins that interact with cell plasma membranes by damaging the membranes (pore formation) or stimulating cell receptors (superantigens). This is the most current reference work on these important bacterial protein toxins, which are presented from the point of view of different disciplines such as pharmacology, microbiology, cell biology and protein chemistry.
Table des matières
1 Uptake of Protein Toxins Acting Inside Cells.- 2 Common Features of ADP-Ribosyltransferases.- 3 Diphtheria Toxin and the Diphtheria-Toxin Receptor.- 4 Pseudomonas aeruginosa Exotoxin A: Structure/Function, Production, and Intoxication of Eukaryotic Cells.- 5 Diphtheria-Toxin-Based Fusion-Protein Toxins Targeted to the Interleukin-2 Receptor: Unique Probes for Cell Biology and a New Therapeutic Agent for the Treatment of Lymphoma.- 6 Structure and Function of Cholera Toxin and Related Enterotoxins.- 7 Mechanism of Cholera Toxin Action: ADP-Ribosylation Factors as Stimulators of Cholera Toxin-Catalyzed ADP-Rihosylation and Effectors in Intracellular Vesicular Trafficking Events.- 8 Pertussis Toxin: Structure-Function Relationship.- 9 Pertussis Toxin as a Pharmacological Tool.- 10 Clostridium Botulinum C3 Exoenzyme and C3-Like Transferases.- 11 Pseudomonas aeruginosa Exoenzyme S, a Bifunctional Cytotoxin Secreted by a Type-III Pathway.- 12 Structure and Function of Actin-Adenosine-Diphosphate-Ribosylating Toxins.- 13 Molecular Biology of Actin-ADP-Ribosylating Toxins.- 14 Molecular Mechanisms of Action of the Large Clostridial Cytotoxins.- 15 Molecular Biology of Large Clostridial Toxins.- 16 The Cytotoxic Necrotizing Factor 1 from Escherichia Coli.- 17 Shiga Toxins of Shigella dysenteriae and Escherichia coli.- 18 Clostridial Neurotoxins.- 19 Anthrax Toxin.- 20 Adenylyl-Cyclase Toxin from Bordetella pertussis.- 21 Helicobacter Pylori Vacuolating Cytotoxin.- 22 Staphylococcal a Toxin.- 23 Bacterial Phospholipases.- 24 Pore-Forming Toxins as Cell-Biological and Pharmacological Tools.- 25 Heat-Stable Enterotoxin of Escherichia Coli.- 26 Superantigenic Toxins.- 27 Structure and Activity of Endotoxins.- 28 Translocated Toxins and Modulins of Yersinia.
