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This volume presents the proceedings of the Symposium on "Hypertension . Mechanisms and Management" held at the "Akademie der Wissenschaften" in Mainz on the 1st and 2nd October, 1979. The Symposion has been dedicated to Professor Hanns-Peter Wolff, who has been the Chairman of the First De partment ofIntemal Medicine at the University of Mainz since 1968, on the occasion of his 65th birthday. The conference was mainly devoted to pathophysiological aspects of high blood pressure. A first series of papers discussed the possible role of the sympathetic nervous system in the pathogenesis of arterial hypertension. Despite consider able methodological progress made in the measurement of circulating catechol amines it is still unclear whether catecholamines are raised in essential hyper tension, and if so, whether this is important for the pathogenesis of high blood pressure. Practically all papers of the first session were related to this question. For several decades the renin-angiotensin system has been the central topic of any hypertension meeting. We thought that additional lectures or papers on this subject might fail to provide new aspects. We therefore asked five experts who have been working in this field for many years to discuss in a Round Table whether or not the renin-angiotensin system might playa significant role in human hypertension. A further topic were the renal tissue hormones other than renin-angiotensin. The papers discussed in particular kallikrein and its possible role in activating renin and thereby possibly contributing to high blood pressure.
Table des matières
Sympathetic Nervous System and Hypertension.- Circulatory Neurohormones in Primary Hypertension: Probes in Etiology and Treatment.- Plasma Catecholamine Levels and the Renin-Angiotensin-System in Subjects with Borderline Hypertension.- Sympathetic Nervous Activity, Noradrenaline Reactivity, and Blood Pressure Control.- Cardiovascular Pressor Reactivity as Related to Plasma Catecholamines: Role in the Pathogenesis of Essential Hypertension and in the Antihypertensive Mechanism of Diuretic Treatment.- Blunting of Beta-Adrenoceptor-Mediated Cardiovascular Responses and Increasing Alpha-Receptor-Mediated Vasoconstriction: An Age-Dependent Transformation of Essential Hypertension.- Patterns of Noradrenaline and Renin in Essential Hypertension - Effects of Stress and Therapy.- Catecholamines, Isometric Exercise and Left Ventricular Function.- Plasma Noradrenaline as an Index of Sympathetic Activity.- Free Communications.- The Central Peptidergic Stimulation Syndrome: A Role for Brain Peptides in Central Mechanisms of Blood Pressure Regulation.- Glandular Adenylate Cyclase System in Genetic Hypertension - Age-Dependent Response to Catecholamines.- Effects of Somatostatin on Pressor Responsiveness to Angiotensin and Catecholamines in Essential Hypertension.- Acute Effects of Labetalol on Haemodynamics and Response to Emotional Stress in Hypertensive Patients.- Round Table Discussion: Does the Renin-Angiotensin System Play a Significant Role in Human Hypertension?.- Renal Hormones.- Renal Vasodepressor Hormones: The Kallikrein-Kinin and Prostaglandin Systems.- Plasma Kallikrein as an Activator of Inactive Renin ("Prorenin") - Studies In-Vitro and In-Vivo.- Urinary Kallikrein Activity in Rats with Renovascular Hypertension.- Enhanced Parotid Kallikrein Secretion inEssential, Adrenal Hypertension and in Advanced Renal Failure - Inverse Relationship to Sodium Excretion.- Identification of Angiotensin II- and Kinin-Dependent Mechanisms in Essential Hypertension.- Free Communications.- Interactions Between Angiotensin II and ACTH on the Human Adrenal Gland.- Disturbed Regulation of Aldosterone and Sodium Excretion in a Subgroup of Essential Hypertensives.- Studies on the Influence of Salt and Water Balance and Blood Pressure Regulation in Hypertensive Patients.- Hypertension and Public Health.- An Overview of the National High Blood Pressure Education Program in the United States.- Campaigns Against High Blood Pressure in Switzerland and the National Research Program 1 "Methodology of Primary Prevention of Cardiovascular Diseases".- Rundtisch-Gespräch: Möglichkeiten der Hypertonieintervention in Deutschland.
