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The past two decades have seen an ever-accelerating growth in knowledge about molecular pathology of human diseases, which received a large boost with the sequencing of the human genome in 2003. Molecular diagnostics, molecular targeted therapy and genetic therapy, are now routine in many medical centers. The molecular field now impacts every field in medicine, whether clinical research or routine patient care. There is a great need for basic researchers to understand the potential clinical implications of their research whereas private practice clinicians of all types (general internal medicine and internal medicine specialists, me- cal oncologists, radiation oncologists, surgeons, pediatricians, family practitioners), clinical investigators, pathologists and medical laboratory directors and radiologists require a basic understanding of the fundam- tals of molecular pathogenesis, diagnosis, and treatment for their patients. Traditional textbooks in molecular biology deal with basic science and are not readily applicable to the medical setting. Most medical textbooks that include a mention of molecular pathology in the clinical s- ting are limited in scope and assume that the reader already has a working knowledge of the basic science of molecular biology. Other texts emphasize technology and testing procedures without integrating the clinical perspective. There is an urgent need for a text that fills the gap between basic science books and clinical practice. In the Molecular Pathology Library series, the basic science and the technology is integrated with the medical perspective and clinical application.
Table des matières
Molecular Pathology of Hematolymphoid Neoplasms: General Principles.- Molecular Oncogenesis.- Genetic Predispositions for Hematologic and Lymphoid Disorders.- Prognostic Markers.- Cancer Stem Cells: Potential Targets for Molecular Medicine.- Gene Therapy for Leukemia and Lymphoma.- Chemical and Environmental Agents (Including Chemotherapeutic Agents and Immunosuppression).- Viral Oncogenesis.- Specific Techniques and Their Applications in Molecular Hematopathology.- Techniques to Determine Clonality in Hematolymphoid Malignancies.- Techniques to Detect Defining Chromosomal Translocations/Abnormalities.- Molecular Techniques to Detect Disease and Response to Therapy: Minimal Residual Disease.- Detection of Resistance to Therapy in Hematolymphoid Neoplasms.- Monitoring Engraftment of Bone Marrow Transplant by DNA Fingerprinting.- Gene Expression Profiling.- Proteomics of Human Malignant Lymphoma.- Mouse Models of Hematolymphoid Malignancies.- Molecular Pathology of Hematolymphoid Neoplasms: Specific Subtypes.- Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma.- Marginal Zone B-Cell Lymphoma.- Lymphoplasmacytic Lymphoma.- Molecular Pathology of Plasma Cell Neoplasms.- The Roles of Molecular Techniques in the Diagnosis and Management of Follicular Lymphoma.- Mantle Cell Lymphoma.- Diffuse Large B-Cell Lymphomas.- The Molecular Pathology of Burkitt Lymphoma.- Precursor B-Cell Acute Lymphoblastic Leukemia.- Molecular Genetics of Mature T/NK Neoplasms.- Precursor T-Cell Neoplasms.- Classical Hodgkin Lymphoma and Nodular Lymphocyte Predominant Hodgkin Lymphoma.- Posttransplant Lymphoproliferative Disorder.- AIDS-Related Lymphomas.- Chronic Myelogenous Leukemia.- Molecular Pathogenesis of Nonchronic Myeloid Leukemia Myeloproliferative Neoplasms.- Molecular Pathology of Myelodysplastic/Myeloproliferative Neoplasms, Myeloid and Lymphoid Neoplasms with Eosinophilia and Abnormalities of PDGFRA, PDGFRB, and FGFR1, and Mastocytosis.- Molecular Pathogenesis of Myelodysplastic Syndromes.- Acute Myeloid Leukemias with Recurrent Cytogenetic Abnormalities.- Acute Myeloid Leukemias with Normal Cytogenetics.- Acute Myeloid Leukemia with Myelodysplasia-Related Changes and Therapy-Related Acute Myeloid Leukemia.- Molecular Pathology of Hemoglobin and Erythrocyte Membrane Disorders.- White Blood Cell and Immunodeficiency Disorders.- Molecular Basis of Disorders of Hemostasis and Thrombosis.- Sarcoidosis: Are There Sarcoidosis Genes?.- Castleman's Disease.- Molecular Pathology of Histiocytic Disorders.- Reactive Lymphadenopathies: Molecular Analysis.- Molecular Pathology of Infectious Lymphadenitides.- Gene Therapy for Nonneoplastic Hematologic and Histiocytic Disorders.
Résumé
The past two decades have seen an ever-accelerating growth in knowledge about molecular pathology of human diseases, which received a large boost with the sequencing of the human genome in 2003. Molecular diagnostics, molecular targeted therapy and genetic therapy, are now routine in many medical centers. The molecular field now impacts every field in medicine, whether clinical research or routine patient care. There is a great need for basic researchers to understand the potential clinical implications of their research whereas private practice clinicians of all types (general internal medicine and internal medicine specialists, me- cal oncologists, radiation oncologists, surgeons, pediatricians, family practitioners), clinical investigators, pathologists and medical laboratory directors and radiologists require a basic understanding of the fundam- tals of molecular pathogenesis, diagnosis, and treatment for their patients. Traditional textbooks in molecular biology deal with basic science and are not readily applicable to the medical setting. Most medical textbooks that include a mention of molecular pathology in the clinical s- ting are limited in scope and assume that the reader already has a working knowledge of the basic science of molecular biology. Other texts emphasize technology and testing procedures without integrating the clinical perspective. There is an urgent need for a text that fills the gap between basic science books and clinical practice. In the Molecular Pathology Library series, the basic science and the technology is integrated with the medical perspective and clinical application.
