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Informationen zum Autor Amitava Dasgupta, Ph.D, DABCC, FACB, Professor of Pathology and Laboratory Medicine, University of Texas Health Sciences Center at Houston, Houston, TX. Loralie J. Langman, Ph.D, DABCC, FACB, Associate Professor of Laboratory Medicine, Mayo Clinic, Rochester, MN. Klappentext Pharmacogenomics is the basis of personalized medicine which will be the medicine of the future. Through both reducing the numbers of adverse drug reactions and improving the use of existing drugs in targeted populations, pharmacogenomics represents a real advance on traditional therapeutic drug monitoring.Pharmacogenomics in Clinical Therapeutics provides an introduction to the principles of pharmacogenomics before addressing the pharmacogenomic aspects of key therapeutic areas such as warfarin therapy, cancer chemotherapy, therapy with immunosuppressants, antiretroviral therapy, and psychoactive drugs. It also includes methods of pharmacogenomic testing and the pharmacogenomic aspects of drug-drug interactions.From a team of expert contributors, Pharmacogenomics in Clinical Therapeutics is a comprehensive overview of the current state of pharmacogenomics in pharmacotherapy for all clinicians, pharmacologists and clinical laboratory professionals. It is also a guide for practicing clinicians and health care professionals to the basic principles of pharmacogenomics, laboratory tests currently available to aid clinicians, and the future promise of this developing field. Zusammenfassung Pharmacogenomics is the process of analyzing patients' genes to predict the onset of adverse reactions or forecast the effectiveness of therapeutic drugs. This useful text is written to discuss both the theory and the clinical application of the principles of pharmacogenomics. Inhaltsverzeichnis List of Contributors, viiPreface, ix1 Pharmacogenomics Principles: Introduction to Personalized Medicine, 1Parvaz Madadi, PhD and Gideon Koren, MD2 Traditional Therapeutic Drug Monitoring and Pharmacogenomics: Are They Complementary? 15Christine L.H. Snozek, PhD, Loralie J. Langman, PhD, and Amitava Dasgupta, Ph.D3 Pharmacogenomics Aspect of Warfarin Therapy, 26Matthew D. Krasowski, MD, PhD4 Pharmacogenetics and Cancer Chemotherapy, 39Christine L.H. Snozek5 Pharmacogenomic Considerations in Anesthesia and Pain Management, 53Christine M. Formea, PharmD and Wayne T. Nicholson, MD, PharmD6 Pharmacogenomics of Immunosuppressants, 70Nicolas Picard, PharmD, PhD and Pierre Marquet, MD, PhD7 Pharmacogenomics of Cardiovascular Drugs, 98Linnea M. Baudhuin, PhD8 Pharmacogenomic Aspects of Antiretroviral Therapy, 127Natella Y. Rakhmanina, MD, PhD and John N. van den Anker, MD, PhD9 Pharmacogenetics of Psychoactive Drugs, 144Jorge L. Sepulveda, MD, PhD10 Pharmacogenomic Aspects of Adverse Drug-Drug Interactions, 176Loralie J. Langman, PhD and Christine L.H. Snozek, PhD11 Microarray Technology and Other Methods in Pharmacogenomics Testing, 185Jorge L. Sepulveda, MD, PhD12 Pharmacogenetic Testing in the Clinical Laboratory Environment, 201Mark P. Borgman, PhD and Mark W. Linder, PhDIndex, 225...
