Mucosal Vaccines - Modern Concepts, Strategies, and Challenges

This volume is focused on the development of vaccines which generate immune effectors capable of blocking mucosal entry or peripheral pathogen spread. A critical first step in the design of mucosal vaccines is the selection of administration route. Not all mucosal immunization routes are created equally when it comes to eliciting immune responses in multiple body compartments. This subject and situations when a mucosal route may not be required for vaccine delivery are reviewed here with an emphasis on the sublingual immunization route, which may offer a safer alternative to the nasal route for induction of broadly disseminated immune responses. External host defenses that inhibit entry of microorganisms at mucosal surfaces also pose obstacles to the efficient internalization of mucosally-applied vaccines. Transcutaneous immunization with appropriate adjuvants and permeation enhancers can induce mucosal immune responses and may be advantageous for bypassing these luminal barriers. Other chapters describe strategies for enhancing uptake of mucosal vaccines, for instance through targeted delivery to antigen-sampling M cells, construction of virus-like particles which mimic natural pathogens, addition of mucoadhesives or formulation as nanoparticles. Topics include edible vaccines as well as plant-based production of subunit or particulate vaccines that could be administered by any route. Dry powder vaccines that could be insufflated or directly applied to mucosal surfaces may be particularly ideal for mass vaccination in developing countries. The manufacture, stability and efficacy of powder formulations is comprehensively reviewed. We conclude with chapters on two of the greatest challenges facing mucosal vaccine development: human immunodeficiency virus and bioterrorist agents. This monograph highlights progress and information that should prove invaluable for the development of contemporary vaccines that prevent infection by these and other mucosal pathogens. Most human pathogens utilize mucosal surfaces to access the host. This volume is focused on the development of vaccines which generate immune effectors capable of blocking mucosal entry or peripheral pathogen spread. A critical first step in the design of mucosal vaccines is the selection of administration route. Not all mucosal immunization routes are created equally when it comes to eliciting immune responses in multiple body compartments. This subject and situations when a mucosal route may not be required for vaccine delivery are reviewed here with an emphasis on the sublingual immunization route, which may offer a safer alternative to the nasal route for induction of broadly disseminated immune responses. External host defenses that inhibit entry of microorganisms at mucosal surfaces also pose obstacles to the efficient internalization of mucosally-applied vaccines. Transcutaneous immunization with appropriate adjuvants and permeation enhancers can induce mucosal immune responses and may be advantageous for bypassing these luminal barriers. Other chapters describe strategies for enhancing uptake of mucosal vaccines, for instance through targeted delivery to antigen-sampling M cells, construction of virus-like particles which mimic natural pathogens, addition of mucoadhesives or formulation as nanoparticles. Topics include edible vaccines as well as plant-based production of subunit or particulate vaccines that could be administered by any route. Dry powder vaccines that could be insufflated or directly applied to mucosal surfaces may be particularly ideal for mass vaccination in developing countries. The manufacture, stability and efficacy of powder formulations is comprehensively reviewed. We conclude with chapters on two of the greatest challenges facing mucosal vaccine development: human immunodeficiency virus and bioterrorist agents. This monograph highlights progress and information that should prove invaluable for the development of contemporary vaccines that prevent infection by these and other mucosal pathogens.

Table des matières

Preface.- Mucosal Delivery Routes for Optimal Immunization: Targeting Immunity to the Right Tissues.- Mucosal Immune Responses Induced by Transcutaneous Vaccines.- Advances in Mucosal Vaccine Development: M Cell-targeted Vaccines.-Microparticle and Nanoparticle Delivery Vehicles for Mucosal Vaccination.- Virus-Like Particles for Antigen Delivery at Mucosal Surfaces.- Plant-derived Antigens as Mucosal Vaccines.- Dry Powder Mucosal Vaccines: Critical Factors for Effective Manufacture and Delivery.- Mucosal Vaccines for Biodefense.-Mucosal Immunity and HIV Infection: Applications for Mucosal AIDS Vaccine Development.- Subject index

Résumé

This volume is focused on the development of vaccines which generate immune effectors capable of blocking mucosal entry or peripheral pathogen spread. A critical first step in the design of mucosal vaccines is the selection of administration route. Not all mucosal immunization routes are created equally when it comes to eliciting immune responses in multiple body compartments. This subject and situations when a mucosal route may not be required for vaccine delivery are reviewed here with an emphasis on the sublingual immunization route, which may offer a safer alternative to the nasal route for induction of broadly disseminated immune responses. External host defenses that inhibit entry of microorganisms at mucosal surfaces also pose obstacles to the efficient internalization of mucosally-applied vaccines. Transcutaneous immunization with appropriate adjuvants and permeation enhancers can induce mucosal immune responses and may be advantageous for bypassing these luminal barriers. Other chapters describe strategies for enhancing uptake of mucosal vaccines, for instance through targeted delivery to antigen-sampling M cells, construction of virus-like particles which mimic natural pathogens, addition of mucoadhesives or formulation as nanoparticles. Topics include edible vaccines as well as plant-based production of subunit or particulate vaccines that could be administered by any route. Dry powder vaccines that could be insufflated or directly applied to mucosal surfaces may be particularly ideal for mass vaccination in developing countries. The manufacture, stability and efficacy of powder formulations is comprehensively reviewed. We conclude with chapters on two of the greatest challenges facing mucosal vaccine development: human immunodeficiency virus and bioterrorist agents. This monograph highlights progress and information that should prove invaluable for the development of contemporary vaccines that prevent infection by these and other mucosal pathogens.

Texte suppl.

From the reviews:
“This is a neat little book giving a good overview of the world of mucosal vaccines. … Each chapter has a comprehensive list of references and some pleasing figures … . I would recommend that any institution working on vaccine development should invest in a copy. It would be particularly useful for a first year PhD student embarking on a vaccine development project.” (Helen Ambrose, Microbiology Today, November, 2012)

Commentaire

From the reviews:
"This is a neat little book giving a good overview of the world of mucosal vaccines. ... Each chapter has a comprehensive list of references and some pleasing figures ... . I would recommend that any institution working on vaccine development should invest in a copy. It would be particularly useful for a first year PhD student embarking on a vaccine development project." (Helen Ambrose, Microbiology Today, November, 2012)

Détails du produit

• Collaboration: Pamel A Kozlowski (Editeur), Pamela A Kozlowski (Editeur), Pamela Kozlowski (Editeur), Pamela A. Kozlowski (Editeur)
• Edition: Springer, Berlin
• Langues: Anglais
• Format d'édition: Livre Relié
• Sortie: 01.08.2011
• EAN: 9783642236921
• ISBN: 978-3-642-23692-1
• Pages: 198
• Poids: 426 g
• Illustrations: X, 198 p.
• Thèmes: Current Topics in Microbiology and Immunology; Current Topics in Microbiology and Immunology
• Catégories: Sciences naturelles, médecine, informatique, technique > Médecine > Pharmacie; B, Immunologie, Immunology, Pharmacology, Vaccine, Biomedical and Life Sciences, Antibodies, Vaccines, Adaptive Immunity