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Bacillus anthracis causes anthrax in all mammals, including humans. Depending upon the route of entry of B. anthracis spores, infection can result in cutaneous lesions, which are readily treatable with antibiotics, or systemic lethal disease, which is nearly always fatal. The continuing worldwide incidence of anthrax in animal populations, the risk of human infection associated with animal outbreaks, and the threat of use of B. anthracis as a biological weapon warrant continued investigation of this organisms and its virulence mechanims. Furthermore, B. anthracis is an excellent model system for inverstigation of virulence gene expression by bacteria.
Inhaltsverzeichnis
List of Contents.- Introduction: Anthrax History, Disease and Ecology.- Bacillus anthracis Evolution and Epidemiology.- Anthrax Vaccines.- Structure and Function of Anthrax Toxin.- Bacillus anthracis Cell Envelope Components.- Macrophage Interactions.- Bacillus anthracis Genetics and Virulence Gene Regulation.
Zusammenfassung
Bacillus anthracis causes anthrax in all mammals, including humans. Depending upon the route of entry of B. anthracis spores, infection can result in cutaneous lesions, which are readily treatable with antibiotics, or systemic lethal disease, which is nearly always fatal. The continuing worldwide incidence of anthrax in animal populations, the risk of human infection associated with animal outbreaks, and the threat of use of B. anthracis as a biological weapon warrant continued investigation of this organisms and its virulence mechanims. Furthermore, B. anthracis is an excellent model system for inverstigation of virulence gene expression by bacteria.
Zusatztext
From the reviews:
"Interest in anthrax largely occurs in waves as international concern over its intentional release waxes and wanes. This monograph concentrates on research from 1990s with a fascinating historical introduction … . A highly readable short book that provides an authoritative account of the current status of anthrax and highlights the need for further work in several areas." (Fergus Priest, Microbiology Today, Vol. 30, 2003)
"Last year Bacillus anthracis rose to sad eminence by the bioterrorist attacks in the United States. This is already mentioned in this volume of Current Topics in Microbiology and Immunology which comprises a wealth of data from the early beginning of research to the present day. … The book, written by 13 authors, came in the very nick of time and it links together in a laudable manner history and state-of-the-art research." (W. Köhler, International Journal of Medical Microbiology, Issue 5-6, 2002)
Bericht
From the reviews:
"Interest in anthrax largely occurs in waves as international concern over its intentional release waxes and wanes. This monograph concentrates on research from 1990s with a fascinating historical introduction ... . A highly readable short book that provides an authoritative account of the current status of anthrax and highlights the need for further work in several areas." (Fergus Priest, Microbiology Today, Vol. 30, 2003)
"Last year Bacillus anthracis rose to sad eminence by the bioterrorist attacks in the United States. This is already mentioned in this volume of Current Topics in Microbiology and Immunology which comprises a wealth of data from the early beginning of research to the present day. ... The book, written by 13 authors, came in the very nick of time and it links together in a laudable manner history and state-of-the-art research." (W. Köhler, International Journal of Medical Microbiology, Issue 5-6, 2002)
