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After a little more than 20 years since the original discovery of neuropeptide Y (NPY) by Tatemoto and colleagues, the field of NPY research has made remarkable progress and is coming of age.The present volume addresses all major topics in connection with NPY and related peptides by established leaders in their respective areas. Experienced NPY-aficionados will certainly find new and useful additional information in this volume and newcomers to the field will hopefully discover how much exciting research this still has to offer.
Inhaltsverzeichnis
Neuropeptide Y: History and Overview.- PP, PYYand NPY: Synthesis, Storage, Release and Degradation.- NPY Receptor Subtypes and Their Signal Transduction.- Phylogeny of NPY-Family Peptides and Their Receptors.- Neuropeptide Y and Its Receptor Subtypes in the Central Nervous System: Emphasis on Their Role in Animal Models of Psychiatric Disorders.- Prejunctional Effects of Neuropeptide Y and Its Role as a Cotransmitter.- Neuroendocrine Actions Of Neuropeptide Y.- NPY: A Novel On/Off Switch for Control of Appetite and Reproduction.- Behavioral Effects of Neuropeptide Y.- NPY Effects on Food Intake and Metabolism.- Neuropeptide Yand Cardiovascular Function.- Neuropeptide Y and the Kidney.- NPY-Like Peptides, Y Receptors and Gastrointestinal Function.- NPY and Immune Functions: Implications for Health and Disease.- Transgenic and Knockout Models in NPY Research.- Structure-Activity Relationship of Peptide-Derived Ligands at NPY Receptors.- Structure-Activity Relationships of Nonpeptide Neuropeptide Y Receptor Antagonists.
Zusammenfassung
After a little more than 20 years since the original discovery of neuropeptide Y (NPY) by Tatemoto and colleagues, the field of NPY research has made remarkable progress and is coming of age.The present volume addresses all major topics in connection with NPY and related peptides by established leaders in their respective areas. Experienced NPY-aficionados will certainly find new and useful additional information in this volume and newcomers to the field will hopefully discover how much exciting research this still has to offer.
