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Informationen zum Autor Dr Pavel Broz MD is at the University Hospital Basel, Switzerland. Klappentext Nanotechnology is about small things and medicine usually deals with bigger things - with patients and their diseases. This book combines both viewpoints and presents successful applications of nanotechnological constructs in medicine and the science behind the tools. Supramolecular nanometre-sized structures such as nanoparticles or vesicles built out of new synthetic polymeric materials have aroused enormous interest in recent years - both in chemical and pharmaceutical labs as well as in clinical medicine. They promise to be useful for novel or improved diagnostic and therapeutic applications for important diseases such as arteriosclerosis, cancer, infections, or autoimmune disorders. In the first part of this book, renowned researchers provide a detailed insight into both chemical and biological/pharmacological basics that have to be managed for successful applications of these nanostructures in human beings. In the second part, invited authors review the main literature in both diagnostic and therapeutic applications with polymer-based nanostructures that have already reached clinical practice or will enter it in the next few years. Key features include: -Multidisciplinary: The book is written by both clinicians from world-wide leading University Hospitals as well as researchers coming from natural sciences. Special effort was invested into comprehensibility across the traditional borders of medicine, pharmacology, and chemistry. -State-of-the-art: The book is filled with exciting contributions from some of the leading research groups in the field. This guarantees a clear emphasis on ongoing research and ground-breaking applications and projects -Structure: The book can be read from the beginning to the end, starting with basics that help to understand the current diagnostic and therapeutic applications of polymer-based nanostructures in medicine, ending with innovative multifunctional and "smart" nanostructures that might be the future of medicine. The way leads from solid foundations to nowadays applications and further to more futuristic approaches -References: The internationally renowned authors of the chapters have put great efforts into choosing only the most important and competitive papers for the reference lists. All major projects in this field are included - perfect for students or researchers that want to search the main literature thus avoiding the need to search through huge electronic databases Zusammenfassung Summarises the recent knowledge in this field and presents successful applications of polymer-based supramolecular nanometre-sized structures in medicine - both in diagnostic and therapeutic applications. Inhaltsverzeichnis 1 - Foreword; 2 - Basics; Polymer materials for biomedical application; Factors influencing the polymer's applicability in biomedical fields; References; Contact; Strategies for transmembrane passage of polymer-based nanostructures; Introduction; Peptides and proteins delivery; Gene delivery; General vaccines delivery; Nanoparticles; Strategies for Transmembrane Passage of Polymer-Based Nanostructures; Gastrointestinal Transepithelial Permeability of Polymer-Based Nanostructures; Mechanisms of Transepithelial Transport of Nanoparticles; Paracellular Pathway; Transcellular Pathway; Strategies for Transepithelial Permeability of Polymer-Based Nanostructures through the Paracellular Pathway; Strategies for Transepithelial Permeability of Polymer-Based Nanostructures through the Transcellular Pathway; Modification of Polymer-Based Nanostructure Surfaces with Targeting Moieties (Targeted Delivery Systems); Gastrointestinal Targeting of Nanoparticles with Surfaces Modified by Lectins; M Cell Targeting with Polymer-Based Nanostructures Decorated With Lectins on the Surface; Capability of M cells to absorb non-targeted nanoparticles; Strate...
