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Dieser Band aus der Reihe "Methods and Principles in Medicinal Chemistry" beleuchtet die Rolle molekularer Wirkstofftransporter im Kontext der Therapieoptimierung und der Aufklärung von Wirkstoffresistenzen. Alle bekannten Transporterklassen (vom Mikroorganismus bis zum Menschen) werden vorgestellt. Die ideale Ergänzung zu "Transporters as Drug Targets" (Gundertofte) aus derselben Reihe!
Inhaltsverzeichnis
PART 1 1 The ABC Transporters: Structural Insights into Drug Transport2 Biochemistry, Physiology, and Pharmacology of Nucleoside and Nucleobase Transporters3 Organic Anion Transporting Polypeptides (Oatps/OATPs)4 CNS Transporters as Drug TargetsPART 2 5 Bacterial Multidrug Transporters: Molecular and Clinical Aspects6 Pleiotropic drug resistance in yeast and fungal pathogensPART 3 7 QSAR studies on ABC-transporters: how to deal with polyspecificity8 Drug Transporter PharmacophoresPART 4 9 Biological Membranes and Drug Transport10 Transport at the Blood-Brain Barrier11 Bile canalicular transporters 12 Interplay of Cytochrome P450 Isoenzymes and ABC-transporter13 ABC-Transporter: From target to antitargetPART 3 14 A Systems Biology View of Drug Transporters15 Drug Transporters in Health and Disease
Über den Autor / die Autorin
Gerhard Ecker is the head of the Pharmacoinformatics Initiative at the Department of Medicinal Chemistry, University of Vienna. He studied Pharmacy at the University of Vienna (Ph.D. thesis advisors: W. Fleischhacker and C.R. Noe) and did post-doctoral work with J. Seydel in Borstel (Germany) where he started his SAR and QSAR studies on P-glycoprotein. His main scientific interests are pharmacoinformatic approaches to target drug efflux pumps, in silico screening methods for promiscuous targets, and non-linear methods in drug design.
Peter Chiba is a senior scientist and lecturer at the Medical University of Vienna. He holds a doctorate in Medicine from the University of Vienna and worked at the Universities of Nijmegen (The Netherlands) and South Florida (USA) as a Fulbright scholar and post-doctoral associate. His research focuses on multidrug transport and resistance to drugs in treatment of cancer and microbial disease.
Zusammenfassung
Dieser Band aus der Reihe "Methods and Principles in Medicinal Chemistry" beleuchtet die Rolle molekularer Wirkstofftransporter im Kontext der Therapieoptimierung und der Aufklärung von Wirkstoffresistenzen. Alle bekannten Transporterklassen (vom Mikroorganismus bis zum Menschen) werden vorgestellt.
Bericht
"Overall, the book is well organized and the topics are clearly and easily accessible. This book offers many strengths ...but overall is quite worthwhile." ( ChemMedChem , January 2011)
"Overall, the book is a specialised text (as reflected in the price) that provides a comprehensive review of drug transporters. It would also be a welcome addition to any well stocked university library." (PJ Online, 12 November 2010)
