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Due to the emergence of organocatalysis as a highly active and very exciting field of research both in academia and the life sciences industry, an Ernst Schering Research Foundation Symposium was organized in 2007 to bring together the scientific leaders in this field and to discuss the basics and current progress of organocatalysis and its application in drug discovery. Various aspects of organocatalysis are addressed in this volume, covering a broad range of synthetic transformations such as functional group interconversions as well as CC- and CX-bond formations and their applications in natural product and drug syntheses. In addition, the design and scope of various catalyst systems are discussed, from small molecules, to peptides, to genetically engineered enzymes.
Inhaltsverzeichnis
Chiral Organocatalysts for Enantioselective Photochemical Reactions.- Organocatalytic Syntheses of Bioactive Natural Products.- Recoverable, Soluble Polymer-Supported Organic Catalysts.- Controlling the Selectivity and Stability of Proteins by New Strategies in Directed Evolution: The Case of Organocatalytic Enzymes.- Biomimetic Organocatalytic C-C-Bond Formations.- N-Heterocyclic Carbenes: Organocatalysts Displaying Diverse Modes of Action.- Organocatalysis by Hydrogen Bonding Networks.- Nucleophilic Carbenes as Organocatalysts.- Asymmetric Organocatalysis on a Technical Scale: Current Status and Future Challenges.- New Concepts for Organocatalysis.- New Developments in Enantioselective Brønsted Acid Catalysis: Chiral Ion Pair Catalysis and Beyond.
Zusammenfassung
This book provides an excellent overview on state-of-the-art of modern organocatalysis. It presents the contributions from leading experts, with backgrounds in academia and industry, to an Ernst Schering Research Foundation Symposium held in April 2007. It will be of interest to those who want a general overview of the topic, but also to those who want to learn more about the state-of-the-art, current trends and perspectives in this highly dynamic field of research.
