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The advent of molecular biology and recombinant DNA technology has profoundly changed contemporary medicine. These new scientific tools have made it possible to identify and understand pathological mechanisms at cellular, subcellular and molecular levels which has added previously unimaginable novel dimensions to the diagnosis, therapy and prevention of a rapidly increasing number of diseases of the liver and biliary system. The title of this book - Acute and Chronic Liver Diseases: Molecular Biology and Clinics - expresses this epochal progress in hepatology.
A series of acute or chronic diseases of the liver has been chosen whose modern clinical management most eloquently reflects the impact of the new scientific insight gained from molecular biology. The book, the proceedings of the 87th Falk Symposium (X International Congress of Liver Diseases: Part II of the Basel Liver Week 1995) held in Basel, Switzerland, October 19-21, 1995, first presents an overview of the molecular pathology of the chosen disease, followed by discussions of the clinical inference which this new scientific information entails for diagnosis, management and therapy. This approach is expected to ease the readers' endeavour to connect basic to clinical science and to facilitate appreciation of the enormous progress but also the inherent limitations and arising questions which modern molecular biology has brought to clinical medicine.
Inhaltsverzeichnis
Introduction; R. Schmid. Section I: Viral Hepatitis. 1. Hepatitis A and E: Molecular Biology; R.H. Purcell, S.U. Emerson. 2. Hepatitis B Viral Variants; J.R. Wands, et al. 3. The Natural History of Chronic Viral Hepatitis Type B and D; M. Rizzetto. 4. Hepatitis C Virus: Molecular Biology and Genetic Variability; C. Brechot. 5. Hepatitis C: Epidemiology and Clinical Course; H.J. Alter. 6. Hepatitis C: Diagnosis and Therapy; A. Alberti, et al. Section II: Biliary Liver Diseases. 7. Molecular Pathogenesis of Cholestasis; J.L. Boyer. 8. Biliary Liver Diseases: Diagnosis, Natural Course and Therapy; G. Paumgartner, U. Beuers. Section III: Toxic Liver Diseases. 9. Pathogenesis and Natural Course of Alcoholic Liver Disease; C.S. Lieber. 10. Therapy of Alcoholic Liver Disease; C. Oneta, et al. 11. Importance of Drug Metabolism for Drug Toxicity; U.A. Meyer. 12. Drug-Induced Hepatotoxicity: Clinical Presentation, Pathogenesis, Risk Factors, Diagnosis and Treatment; S. Krahenbuhl, N. Kaplowitz. Section IV: Metabolic Liver Diseases. 13. Molecular Pathogenesis of Hemochromatosis; C. Camaschella, et al. 14. Hemochromatosis - Recent Diagnostic and Therapeutic Aspects; P. Brissot, et al. 15. Wilson's Disease: Molecular Pathogenesis; T.C. Gilliam. 17. Molecular Pathogenesis of Hepatic Acute Porphyrias; B. Grandchamp, et al. 18. The Clinical Diagnosis, Prevention and Management of the Hepatic Porphyrias; R.J. Hift, et al. 19. Molecular Pathogenesis of Alpha-1-Antitrypsin Deficiency; D.H. Perlmutter. 20. Diagnosis, Clinical Course and Therapy of Alpha-1-Antitrypsin Deficiency; J. Carlson. Section V: Autoimmune Hepatitis. 21. Viruses and Autoimmunity: Hepatitis as a Model. International Hans Popper Award Lecture 1995; M.P. Manns. 22. Molecular Pathogenesis of Autoimmune Hepatitis; M.P. Manns. 23. Autoimmune Hepatitis Diagnosis, Natural Course and Therapy; I.G. McFarlane. Section VI: Fulminant Liver Failure. 24. Molecular Biology of Cell Damage and Death; V.J. Desmet. 25. Clinical Management of Fulminant Hepatic Failure; R. Williams. 26. Fulminant Liver Failure: Prediction of Outcome; G. Grimm, et al. 27. Liver Transplantation in Fulminant Liver Failure; B. Launois, et al. Section VII: Liver Cirrhosis and Hepatocellular Carcinoma. 28. Molecular Fibrogenesis in Liver Injury; S.L. Friedman. 29. Liver Regeneration and the Pathogenesis of Hepatocellular Carcinoma; N. Fausto. 30. Risk Factors and Early Diagnosis of Hepatocellular Carcinoma; M. Colombo. 31. Cirrhosis and Hepatocellular Carcinoma Medical and Interventional Therapy; M.C. Kew. 32. Surgical Therapy in Europe of Hepatocellular Carcinoma in Cirrhosis; H. Bismuth, J.S. Raccuia. 33. Surgical Therapy of Hepatocellular Carcinoma in China; Z.Y. Tang. Index.
Zusammenfassung
Presents an overview of the molecular pathology of liver disease. This book discusses the clinical inference which the scientific information entails for diagnosis, management and therapy.
