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Misuse of psychoactive substances in the form of tobacco, alcohol, cannabis, or prescribed meds, affects the entire family. Besides visible consequences, substance misuse by prospective parents has an invisible target - the progeny. While consequences of some substance use (such as alcohol) on embryonic and fetal development are well known, others are less studied. This book aims at summarizing recent advances in our understanding of how maternal and paternal misuse of psychoactive substances affects the progeny starting from early development and finishing with lifelong consequences. Book aims to cover current knowledge on molecular mechanisms that drive negative consequences of early developmental exposure to well-known drugs of misuse, as well as substances that are traditionally covered to a lesser extend, such as prescription medications, and caffeine. Attention is also given to trans-generational effects of drug misuse, when such misuse occurs before the conception. Lastbut not least, consequences of both maternal and paternal drug misuse are explained. Book will be of interest to a rather large community of students, researchers, and practicians, who tackle everyday challenges of prenatal drug exposure whether at the level of laboratory animal models or at the bedside and at obstetrics offices. Book will also be of value to health- and childcare professionals, as it explains lifelong consequences of prenatal exposure to drugs of misuse. Chapters in the book are contributed by renowned experts in the respective fields, from all across the globe. The overarching goal of this book is to create a comprehensive collection of articles that reflect current knowledge in the field of substance abuse and early development, and to raise the professional awareness of this critical, yet, often under-recognized issue.
Inhaltsverzeichnis
Chapter 1. Animal models of Prenatal Alcohol Exposure.- Chapter 2. Impact of Prenatal Alcohol Exposure on the Cerebral Circulation: Potential Implications for Stroke.- Chapter 3. The Role of the Hedgehog Pathway in Alcohol-Induced Birth Defects.- Chapter 4. Prenatal exposure to low alcohol and alcohol motivation in the offspring.- Chapter 5. Anxiety, depression, and emotional dysregulation following prenatal substance exposure.- Chapter 6. Impact of prenatal alcohol exposure on cerebral cortex development.- Chapter 7. Prenatal alcohol exposure: impact on neuroimmune function in the stress response and pain.- Chapter 8. Prenatal alcohol exposure and mitochondrial function in the brain.- Chapter 9. Prenatal Cannabis And Tobacco: Studies In Animal Models.- Chapter 10. Maternal Caffeine Consumption and Pregnancy Outcomes.- Chapter 11. Animal Models of Prenatal Opioid Exposure: Insights into Impaired Neurodevelopment.- Chapter 12. Prenatal Opioid Exposure and Neonatal Opioid Withdrawal Syndrome.
