Heart Failure in the Child and Young Adult - From Bench to Bedside

Inhaltsverzeichnis

Section I Basic science of heart failure
1. From molecular and cellular mechanisms to models of heart failure
2. Cardiovascular receptors and signaling in heart failure
3. Heart failure in the child and young adult: From bench to bedside: Inflammatory mediators in heart failure
4. Transcriptional regulation, epigenetic regulation, and transcriptomics of pediatric heart failure
5. Mechanisms of hypertrophy in heart failure
6. Hemodynamic adaptive mechanisms in heart failure
7. Neurohormonal axis and natriuretic peptides in heart failure
8. Novel biomarkers in heart failure
9. Systolic and diastolic function
10. Echocardiographic quantitation of ventricular function
11. MRI assessment of heart failure
12. Assessment of heart failure by invasive methods
13. The lymphatic system in heart failure
14. Endothelial dysfunction in heart failure in the child and young adult
Section II Clinical diagnosis and management of pediatric heart failure
15. Epidemiology and economics of pediatric heart failure
16. Clinical recognition of heart failure in children
17. Classification of pediatric heart failure
18. Right ventricular dysfunction
19. Pediatric myocarditis
20. Dilated cardiomyopathy
21. Clinical features of restrictive cardiomyopathy and constrictive pericarditis
22. Hypertrophic cardiomyopathy
23. Left ventricular noncompaction cardiomyopathy
24. Arrhythmogenic cardiomyopathies
25. Valvular insufficiency and heart failure
26. Valvular stenosis and heart failure
27. Coronary artery disease in children and young adults
28. Chronic heart failure in congenital heart disease including single ventricle circulation
29. Heart failure in adults with congenital heart disease
30. Dysrhythmias and ventricular dysfunction and heart failure
31. Fetal heart failure
32. Heart failure in the neonate
33. Heart failure in pediatric pulmonary diseases
34. Pediatric cardiorenal syndrome
35. Heart failure in pediatric oncologic disease
36. Neuromuscular disorders
37. Sickle cell disease
38. The cardiovascular system in systemic inflammatory syndromes
39. Outpatient management of pediatric heart failure
40. Cardiac intensive care and inpatient management of heart failure
41.Quality of life, neurodevelopmental and psychosocial outcomes in pediatric heart failure
42. Palliative care
43. Quality metrics and quality improvement in pediatric heart failure
44. Nursing aspects of heart failure
Section III Medical treatment for pediatric heart failure
45. Diuretic and invasive fluid management strategies
46. Inotropic agents in heart failure
47. Phosphodiesterase inhibitors
48. Use of vasodilators in heart failure
49. Recognition and treatment of low cardiac output states in pediatric cardiac intensive care
50. New therapeutic strategies for heart failure
51. Electrophysiologic devices in heart failure
52.Catheter device therapies for heart failure
Section IV Cardiac surgery and pediatric heart failure
53. Posttransplant heart failure
54. Surgical strategies for the failing single ventricle
55. Valve interventions for heart failure
56. Principles of mechanical cardiopulmonary support
57. Future of mechanical circulatory support devices in children and young adults
58. Short-term mechanical cardiopulmo-nary support devices
59. Decision-making in ventricular assist device support in pediatric advanced heart failure patients
60. Long-term ventricular assist devices in children
Section V Special topics
61. Genetics and genomics
62. Genetic testing
63. Big data and artificial intelligence in pediatric heart failure
64. Outpatient monitoring and self- care
65. Cardiac regenerative medicine for congenital heart defects
66. Development of digital twin models for heart failure patient treatment
67. Nutritional assessment and management in pediatric heart failure
68. The role of wearable technology in improving the care of pediatric heart failure

Über den Autor / die Autorin

Dr. Rossano is the medical director of Pediatric Heart Transplant and Heart Failure. He is also an attending physician in the Cardiac Center and the Cardiac Intensive Care Unit (CICU) and an assistant professor of Pediatrics at the Perelman School of Medicine at the University of Pennsylvania. Dr. Rossano is principal investigator or co-investigator on several ongoing research studies of the use of ventricular assist devices and artificial hearts in children, studying the effectiveness of post-transplant treatments for children who have received heart transplants, an observational study of children with heart failure, and building a registry of pediatric heart transplant patients that aims to further the knowledge of pediatric heart disease and transplantation.Dr. Jefferies is a recognized international expert in the field of heart muscle disease contributing much of the current literature regarding related genetic mechanisms, clinical investigation, and guideline development.Dr. Chang is the founder and medical director of the Medical Intelligence, Information, Investigation, and Innovation Institute (Mi4) that is supported by the Sharon Disney Lund Foundation. The institute is dedicated to the introduction and implementation of artificial intelligence in medicine and was the first institute of its kind in a hospital. Dr. Chang intends to build a clinician-computer scientist interface with a nascent society (the Medical Intelligence Society) and is the editor-in-chief of Intelligence-based Medicine, the accompanying journal for his book, Intelligence-Based Medicine: Artificial Intelligence and Human Cognition in Clinical Medicine and Healthcare. He is the organizing chair for Artificial Intelligence in Medicine (AIMed) meetings around the world, the largest and most comprehensive clinician-led meetings that focus on applications of artificial intelligence in medicine and the dean of the nascent American Board of Artificial Intelligence in Medicine (ABAIM). He is also the founding president of the Medical Intelligence Society (MIS).Dr. Towbin is a recognized international expert in the field of heart muscle disease contributing much of the current literature regarding related genetic mechanisms, clinical investigation, and guideline development.Dr. Shaddy is Chief of the Division of Cardiology at The Children’s Hospital of Philadelphia and holds the Jennifer Terker Endowed Chair in Pediatric Cardiology. He is Professor of Pediatrics and Vice Chair of the Department of Pediatrics at the Perelman School of Medicine at the University of Pennsylvania. Dr. Shaddy brings more than 25 years of experience as a cardiologist caring for children with heart failure to his role as one of the leaders of the transplant program.Dr. Miyamoto is the Director of the Cardiomyopathy Program and Professor of Pediatrics at Children’s Hospital Colorado and the University of Colorado. She is a nationally and internationally recognized authority on pediatric cardiac transplantation and cardiomyopathy, much of her groundbreaking work focuses on the failing heart of children with cardiomyopathies and congenital heart disease.

Produktdetails

• Mitarbeit: Chang Anthony C. (Herausgeber), John Lynn Jefferies (Herausgeber), Shelley Miyamoto (Herausgeber), Robert E Shaddy (Herausgeber), Joseph Rossano (Herausgeber), Towbin Jeffrey A. (Herausgeber)
• Verlag: Elsevier
• Sprache: Englisch
• Produktform: Taschenbuch
• Erschienen: 30.10.2025
• EAN: 9780443132797
• ISBN: 978-0-443-13279-7
• Gewicht: 450 g
• Themen: Naturwissenschaften, Medizin, Informatik, Technik > Medizin > Nichtklinische Fächer; SCIENCE / Life Sciences / General, SCIENCE / Life Sciences / Biology, Biology, life sciences, Life sciences: general issues, Paediatric medicine / child and adolescent medicine