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Bioreactor Design Concepts for Viral Vaccine Production covers a range of interdisciplinary chapters from the engineering perspective of bioreactor design to the biotechnological perspectives of vector design for vaccine development. The book covers bioreactor concepts such as static systems, single-use systems, stirred tanks, perfusion, wave and packed-beds. It reviews options for efficient and economical production of human vaccines and discusses basic factors relevant for viral antigen production in mammalian cells, avian cells, and insect cells. This book will be a great resource for those interested in implemented novel bioreactor design or experimental schemes towards intensified or/and enhanced vaccine production.
Inhaltsverzeichnis
1. Introduction: Understanding of Bioreactor
2. Stoichiometry for Biochemical Process
3. Biochemical aspects of bioreactor operation
4. Scale-Up of Cell-Culture Bioreactors
5. Application of modeling in bioreactor design and analysis
6. Vaccine and Vaccine types
7. Development a new vaccine at lab scale
8. Animal cell cultivation in bioreactor
9. Characterization of cultured animal cells
10. Bioreactor design for vaccine production
11. Advance development in membranes for virus producing bioreactors
12. Downstream Processing for vaccines
13. Vaccine against RNA viruses
14. Vaccine against DNA viruses
15. Development of a bioprocess for rotavirus vaccine
16. Single-use fixed bed bioreactor for scalable virus production
17. Production of rabies vaccine in the large-scale bioreactor
18. Bioreactor for hepatitis C virus vaccine
19. Bioreactor for Vero cell for the production of viral vector and vaccines.
20. Titration and dose calculation of the vaccine stock
21. Bioreactor process development for DNA vaccine production
