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Regenerative Hepatology and Liver Transplantation is the second volume in the
Regenerative and Transplant Medicine series. This volume is essential as no field in the biomedical sciences has more interest than organ transplantation regarding regenerative medicine, primarily because of the urgent need to improve transplant outcomes and increase transplantation rates is critical to treat the many patients suffering from liver disease.
The goal of this book is to bridge regenerative hepatology and transplant medicine, by illustrating the state of the art of clinical liver transplantation, as well as of the progress of regenerative medicine (RM) investigations aiming at the bioengineering, regeneration, and repair of the liver.
This volume is necessary and would be placed well in the current global trend toward increasing organ donation utilizing such cutting-edge technologies. Written by the world’s experts in the field of liver diseases, it is a perfect reference for transplant operators, researchers, regenerative medicine operators, tissue engineering operators, biotech operators, and those in academia, industry, and regulatory agencies working to advance the field.
Inhaltsverzeichnis
Section I: The liver and liver diseases
1. Prevalence of liver disease around the world
Helena Cortez-Pinto, Ana Craciun, Ricardo Crespo and Sofia Carvalhana
2. Viral hepatitis
Jean-Charles Duclos-Vallee
3. Non-alcoholic steatohepatitis
Miguel Pinheiro, Marta B. Afonso and Cec¿lia M.P. Rodrigues
4. Alcoholic liver disease
Zachary DeVore, Philip McNamara, Dimitri Belkin, Naveen Ganjoo and Deepika Devuni
5. Liver fibrosis and cirrhosis
Philipp Schwabl, Margarita Papatheodoridi and Massimo Pinzani
6. Biomarkers in liver disease and transplantation: Outlook for precision medicine
Ruslan A. Mammadov, Vincent T. Janmaat, Cornelia J. Verhoeven, Jan N.M. IJzermans,
Maikel P. Peppelenbosch, Luc J.W. van der Laan and Henk P. Roest
Section II: Liver transplantation
7. Living donor liver transplantation
Han Li, Paulo Martins, Babak Mavahedi and Adel Bozorgzadeh
8. Small-for-size syndrome in liver transplantation
Martin Montenovo
9. Clinical trials design and endpoints in liver transplantation
Richard W. Laing, Amanda P.C.S. Boteon and Yuri L. Boteon
10. Oncologic liver transplantation: Transplant oncology
Taizo Hibi
11. Management of hepatocellular carcinoma
Alejandro Serrablo, Alejandra Utrillas-Fornals, Pablo Parra, Luis Tejedor and Leyre Serrablo
Section III: Cell transplantation
12. Human hepatocyte transplantation
Jessica Nulty, Hanish Anand and Anil Dhawan
13. Mesenchymal stem cell transplantation
M. Najimi, G. de Bodt, G. Jannone and E.M. Sokal
14. Biliary tree stem cell transplantation
Savino Paradiso, Federica Cremisini, Matteo Franchitto, Guido Carpino and Vincenzo Cardinale
Section IV: Liver preservation and machine perfusion
15. General principles of organ preservation in liver transplantation
S.H. Abbas, F. Dengu and P.J. Friend
16. Ischemia-reperfusion injury
Joan Rosello Catafau and Arnau Panisello Rosello
Section V: Regenerative medicine in liver disease and transplantation
17. Liver regeneration
Udayan Apte
18. Whole-liver bioengineering: The future of transplantation medicine
Diogo Marques, Natalia Sanchez Romero, Sandra Meliton Barbancho, Alvaro Blanes Rodriguez, Pilar Sainz de la Masa Arnal, Helen Almeida, Pablo Royo Dachary and Pedro M. Baptista
19. Nanotechnology application in liver transplantation
Christine G. Yao
20. Acute liver failure and bioreactors/liver assist devices
Manon Guillet, Claire de Lartigue, Ulysse Pereira, Marwa Hussein, Mattia Pasqua and Cecile Legallais
21. Hepatobiliary organoids and large-scale expansion for regenerative therapies
Kerstin Schneeberger, Sara Morini and Bart Spee
22. Liver aging
Eric Felli and Jordi Gracia-Sancho
