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This book comprehensively reviews current and novel treatment strategies against human parasites, including protozoans and helminths, using natural products. The initial chapters summarize the conventional treatment strategies and natural-product based therapeutics against these parasites. It discusses biochemical tools and techniques for the discovery of natural product based drugs against human parasites. The book also covers the ingenious and innovative mechanisms to achieve drug resistance by the protozoan parasites and strategies to overcome the resistance. It entails mechanistic insight into the modulation of host immune responses to delay or inhibit parasite clearance and explores host-pathogen interactions that mediate immunity against subsequent parasite challenge. In turn, the volume helps in understanding the immunobiology of the parasites and tools to identify candidate vaccine antigens and novel delivery systems against the protozoan parasites. Lastly, it explores the role of advanced methods, including nanotechnology, marine bioprospecting, and microorganisms-derived biochemicals against the protozoan parasites.
This book is useful for students and researchers of pharmacology, parasitology, zoology and other allied fields.
Inhaltsverzeichnis
Chapter 1. Recent advances on the discovery of plants derived bioactive scaffolds/extracts against parasitic diseases.- Chapter 2. Applications of Computational Methods in Natural Products based Drug Discovery.- Chapter 3. Natural Product-Based Drug Designing for treatment of Human parasitic diseases.- Chapter 4. Secondary Metabolites of Plant Origin in Parasitic manifestations.- Chapter 5. Exploring marine biodiversity as alternative resources for treatment of Human Parasitic Diseases.- Chapter 6. Marine Bioprospecting for the Treatment of Human Parasitic Diseases.- Chapter 7. Microorganisms-Derived Biochemicals: Potential Drugs for Human Parasitic Diseases.- Chapter 8. Plant-Based Vaccines against Human Parasitic Diseases.- Chapter 9. Nanotechnology: its usages in drug delivery for the treatment of Human Parasitic Diseases.- Chapter 10. Therapeutic Potential Of Benzopyrones Against Antiparasitic Diseases.- Chapter 11. Antimicrobial peptides (AMPs): current state and future prospectsfor the treatment of human parasitic diseases.- Chapter 12. Pathway To Register Natural Product-Derived Therapeutics.- Chapter 13. Recent Advances in the Treatment of Parasitic Diseases: Current Status and Future.- Chapter 14. Strategies and challenges for developing plant-based therapeutics against Protozoans.- Chapter 15. Recent approaches to combat toxoplasma gondii with plant-derived alternatives.- Chapter 16. Target-based rational improvement strategies and pitfalls in Leishmania drug discovery.- Chapter 17. Versatile Structurally Diverse Natural Products and Their Semisynthetic Analogs as Potential Anti-leishmanial Drugs.- Chapter 18. Promising compounds of plant origin and their synthetic analogs against Trypanosomes.- Chapter 19. Pathogenesis and Immune Response inT. cruzi infection: Quest for Natural compound-based drugs.- Chapter 20. Limitations of current drugs and prospects of plant-based compounds and their constructed analogues as therapeutics for treatment of malaria.- Chapter 21. An Analytical Approach to Progression in Malaria Therapeutics.- Chapter 22. Malaria Drug Discovery: How to tackle the problem of Drug Resistance.- Chapter 23. Approaches to drug discovery against Ascariasis: Opportunity and challenges in plant-based products.- Chapter 24. The Potential of Plant Secondary Metabolites as Drugs or Leads Against Helminths.- Chapter 25. Drug Resistance in Helminth parasites: Role of plant based natural therapeutics.- Chapter 26. Schistosomiasis: current and future strategies to develop novel therapeutics.
