Neonatal Haematology - A Practical Guide

Neonatal Haematology
 
This unique handbook contains comprehensive coverage of neonatal haematology and aids diagnosis via high-quality images, diagnostic algorithms, case studies, and tables. With illustrations accompanying the diagnosis at each stage and clear explanations provided throughout, the book is ideal for trainees and experts alike.
 
Authored by two of the world's leading haematologists, Professor Irene Roberts and Professor Barbara Bain, this book provides a depth of knowledge that is unequalled in other texts. To aid in reader comprehension, it is neatly organised by clinical problems and covers sample topics such as:
* Red cells: morphology, membrane, enzymes, and changes over the first 4 weeks of life
* Haemolytic anaemias: causes of neonatal haemolysis, diagnostic clues, and immune haemolysis (haemolytic disease of the newborn)
* Neonatal anaemia due to blood loss: causes of blood loss, diagnostic clues, feto-maternal haemorrhage, and twin-to-twin transfusion
* Haematological signs of neonatal infection: causes of neutrophil left shift, leucoerythroblastosis, and toxic granulation
 
Paediatric haematologists, consultant haematologists, and trainees in haematology can use the succinct, well-written content in this book as a useful helping hand during consultation. Biomedical scientists will also value the work as a laboratory reference.

Inhaltsverzeichnis

Preface viii
 
Abbreviations x
 
1 The full blood count and blood film in healthy term and preterm neonates 1
 
Introduction 1
 
Brief outline of the ontogeny of haemopoiesis 1
 
Properties of fetal haemopoietic stem and progenitor cells 2
 
Red blood cell production and development in the fetus and neonate 5
 
Erythropoietin production in the fetus and neonate 6
 
Haemoglobin synthesis and red blood cell production in the fetus and newborn 6
 
Red blood cell lifespan and the red blood cell membrane in the fetus and neonate 9
 
Red blood cell metabolism in the fetus and neonate 10
 
Iron metabolism in the fetus and neonate 11
 
Normal values for red blood cell parameters in the fetus and neonate 12
 
Leucocytes in the fetus and newborn 17
 
Leucocyte production and function in the fetus and neonate 18
 
Platelets and megakaryocytes in the fetus and neonate 23
 
Developmental megakaryopoiesis and thrombopoiesis 23
 
Platelet numbers in the neonate and fetus - normal values 24
 
Neonatal platelet function 25
 
Practical problems in interpreting neonatal blood counts and films 25
 
Sample quality/artefacts 25
 
Site of sampling 26
 
Gestational age and postnatal age 27
 
Pregnancy-associated complications and mode of delivery 28
 
References 28
 
2 Red cell disorders: Anaemia, jaundice, polycythaemia and cyanosis 38
 
Neonatal anaemia 38
 
Definition and clinical significance of neonatal anaemia 38
 
Neonatal anaemia due to reduced red cell production 39
 
Neonatal anaemia due to increased red cell destruction 47
 
Neonatal anaemia due to haemoglobinopathies and other microcytic anaemias 67
 
Neonatal anaemia due to blood loss 76
 
Anaemia of prematurity 81
 
A simple diagnostic approach to neonatal anaemia 83
 
Neonatal polycythaemia 85
 
Haematological causes of cyanosis 86
 
Principles of red cell transfusion in neonates 86
 
Illustrative cases 88
 
Abbreviations used in the illustrative cases 110
 
References 110
 
3 Neonatal infection and leucocyte disorders 128
 
Leucocyte abnormalities in neonatal systemic disease 128
 
Increases in leucocyte numbers 128
 
Neonatal infection and its differential diagnosis: clues from the blood count and blood film 135
 
Storage disorders: diagnostic clues from the blood film 144
 
Neonatal neutropenia 145
 
Definition and causes of neutropenia 145
 
Immune neutropenia 148
 
Inherited congenital or neonatal neutropenia 150
 
Haematological features of neonates with Down syndrome 154
 
Congenital leukaemia 154
 
Leukaemia and preleukaemia in neonates with Down syndrome 156
 
Acute leukaemia in neonates without Down syndrome 160
 
Juvenile myelomonocytic leukaemia and Noonan syndrome myeloproliferative disorder 168
 
Illustrative cases 169
 
Abbreviations used in the illustrative cases 176
 
References 176
 
4 Disorders of platelets and coagulation, thrombosis and blood transfusion 190
 
Thrombocytopenia overview 190
 
Causes of neonatal thrombocytopenia: a practical classification based on age at onset 192
 
Fetal thrombocytopenia 194
 
Early-onset neonatal thrombocytopenia (presenting at
 
Late-onset neonatal thrombocytopenia (presenting at >72 hours of age) 196
 
Conditions leading to clinically significant thrombocytopenia in the neonate 197
 
Fetal/neonatal alloimmune thrombocytopenia 197
 

Über den Autor / die Autorin

Irene Roberts is Emeritus Professor of Paediatric Haematology at the Department of Paediatrics and MRC Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, University of Oxford. She was formerly Professor of Paediatric Haematology at Imperial College London and Honorary Consultant Paediatric Haematologist at St Mary's and Hammersmith Hospitals, Imperial College Healthcare NHS Trust where she established a neonatal haematology diagnostic service based on daily evaluation of peripheral blood films over several decades. Her research focuses on the molecular and biological characteristics of blood disorders in the fetus and early childhood particularly in Down syndrome. Barbara J. Bain is a Professor of Diagnostic Haematology at St Mary's Hospital Campus, Imperial College Faculty of Medicine. She is also a Consultant Haematologist at St Mary's Hospital, London, UK. Her research has been focused on morphology of blood cells, ethnic and biological differences in haematological variables and cytogenetics and molecular genetics in relation to haematological malignancy. She has collaborated with numerous experts in the field and contributed to the WHO Classification of Tumours of Haemopoietic and Lymphoid Tissues.

Produktdetails

• Autoren: Barbara J. Bain, Irene Roberts, Irene (University of Oxford Roberts, Roberts Irene
• Verlag: Wiley, John and Sons Ltd
• Sprache: Englisch
• Produktform: Fester Einband
• Erschienen: 22.09.2022
• EAN: 9781119371588
• ISBN: 978-1-119-37158-8
• Seiten: 304
• Themen: Naturwissenschaften, Medizin, Informatik, Technik > Medizin > Klinische Fächer; Hämatologie, Medizin, Hematology, Medical Science