Mehr lesen
Provides a framework to understand the basis of epigenetic regulation and to appreciate both its derivation from genetics and interdependence with genetic mechanisms. It further aims to highlight the role of the three-dimensional organization of the genetic material itself and its distribution in a functionally compartmentalized nucleus.
Inhaltsverzeichnis
- Part I
- An introduction to epigenetics and epigenetic regulation
- 1: Epigenetic phenomena in fungi, plants and animals
- 2: The basic structure of chromatin
- 3: The basic mechanism of gene transcription
- Part II
- Transcription is regulated by epigenetic mechanisms
- 4: Chromatin modifications and remodeling
- 5: Epigenetic chromatin changes and the transcription cycle
- 6: The role of non-coding RNAs
- 7: Maintenance of the active and inactive states
- 8: DNA methylation and gene expression
- 9: Regulation of domains and whole chromosomes
- Part III
- The interplay between transcription and nuclear structure
- 10: Architectural organization of the genome
- 11: The nuclear envelope
- 12: The nucleolus
- 13: Nuclear bodies
- Part IV
- Inheritance of chromatin structure and functional states
- 14: Chromosome replication and genomic stability
- 15: DNA repair and genomic stability
- 16: Inheritance of chromatin modifications through the cell cycle
- 17: Stem cells
- 18: Nuclear reprogramming and induced pluripotency
- 19: Transgenerational inheritance of epigenetic traits
- Part V
- Epigenetics, human health and development
- 20: Aging, cellular senescence and cancer: The role of genomic instability, cellular homeostasis and telomeres
- 21: Aging, cellular senescence and cancer: Epigenetic alterations and nuclear remodeling
- 22: Developmental systems and their dysfunction
Über den Autor / die Autorin
John Lucchesi obtained a Ph.D. in Genetics from the University of California at Berkeley. Following postdoctoral training in the Institute of Molecular Biology at the University of Oregon, he joined the faculty of the University of North Carolina in Chapel Hill, where he rose to the rank of Cary C. Boshamer Professor of Biology and Genetics. He was appointed Adjunct Professor of Genetics at Duke University and was named Senior Fellow of Churchill College, Cambridge University, UK. In 1990, he joined the faculty of the Biology Department at Emory University as Asa G. Candler Professor of Biology and Chair. Dr Lucchesi is a fellow of the AAAS, a former President of the Genetics Society of America and was named Vice-President of the XVII International Congress of Genetics. His research laboratory has focused on the regulation of transcription, the functional architecture of chromatin and the genetic regulation of development.
Zusammenfassung
Provides a framework to understand the basis of epigenetic regulation and to appreciate both its derivation from genetics and interdependence with genetic mechanisms. It further aims to highlight the role of the three-dimensional organization of the genetic material itself and its distribution in a functionally compartmentalized nucleus.
Zusatztext
This book provides a high-quality and accessible overview of the field of epigenetics, with content organized in a logical sequence . . . [it is] a highly cohesive, logical, and useful volume in which significant content areas are insightfully drawn from the expansive field of epigenetics. It is apparent that the book is written by an individual with a strong breadth of knowledge accumulated from a distinguished career in the field . . . this book, therefore, will be an excellent resource for both those new to epigenetics and seasoned experts
