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Informationen zum Autor GEORGE EDWARD BILLMAN is a professor at The Ohio State University. He is currently an Associate Editor of Pharmacology and Therapeutics , an Editor of Experimental Physiology , and on the editorial boards of Journal of Cardiovascular Pharmacology and Journal of Applied Physiology . Dr. Billman has authored over 125 journal articles and has been an invited speaker at twenty national and international scientific meetings. He wrote the chapter "Cardiac Sarcolemmal ATP-Sensitive Potassium Channel Antagonists" in Drug Discovery Handbook (Wiley). Klappentext PROFILES POTENTIAL TREATMENT APPROACHES FOR CARDIAC ARRHYTHMIAS Cardiac arrhythmias of ventricular origin are responsible for the deaths of nearly half a million Americans each year while atrial fibrillation accounts for about 2.3 million cases per year, a rate that is projected to increase 2.5 fold over the next half century. Effectively managing these cardiac rhythm disorders remains a major challenge for both caregivers and the pharmaceutical industry. Filling a gap in the current literature, Novel Therapeutic Targets for Antiarrhythmic Drugs presents the latest treatments for cardiac arrhythmias alongside comprehensive presentations of basic cardiac physiology and pharmacology. Written by leading experts in their research areas, this invaluable resource offers both practitioners and researchers a one-stop guide that brings together previously dispersed information. The text consists of four sections: Section One comprehensively reviews basic cardiac electrophysiology, the mechanisms responsible for arrhythmias in the setting of ischemia, and basic pharmacology of antiarrhythmic drugs. Section Two addresses safety pharmacology, including the concept of "repolarization reserve," safety challenges, and regulatory issues for the development of novel antiarrhythmic drugs. Section Three describes several novel pharmacological targets for antiarrhythmic drugs, including both ion channel and non-ion channel targets. Section Four describes promising non-pharmacological antiarrhythmic interventions including selective cardiac neural disruption or nerve stimulation, aerobic exercise training, and diet (omega-3 fatty acids). Offering an unparalleled look at the current state and future direction of cardiac arrhythmia treatment, Novel Therapeutic Targets for Antiarrhythmic Drugs provides an important resource to advanced students, working researchers, and busy professionals alike. Zusammenfassung This book provides a comprehensive overview of several promising novel drug targets and approaches against arrhythmias, with particular emphasis placed on malignant ventricular arrhythmias. Inhaltsverzeichnis Acknowledgments xix Contributors xxi 1. Introduction 1 George E. Billman References 3 2. Myocardial K+ Channels: Primary Determinants of Action Potential Repolarization 5 Noriko Niwa and Jeanne Nerbonne 2.1 Introduction 5 2.2 Action Potential Waveforms and Repolarizing K+ Currents 7 2.3 Functional Diversity of Repolarizing Myocardial K+ Channels 9 2.4 Molecular Diversity of K+ Channel Subunits 12 2.5 Molecular Determinants of Functional Cardiac Ito Channels 16 2.6 Molecular Determinants of Functional Cardiac IK Channels 18 2.7 Molecular Determinants of Functional Cardiac Kir Channels 23 2.8 Other Potassium Currents Contributing to Action Potential Repolarization 27 2.8.1 Myocardial K+ Channel Functioning in Macromolecular Protein Complexes 28 References 32 3. The ''Funny'' Pacemaker Current 59 Andrea Barbuti, Annalisa Bucchi, Mirko Baruscotti, and Dario DiFrancesco 3.1 Introduction: The Mechanism of Cardiac Pacemaking 59 3.2 The ''Funny'' Curr...
