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Chromatin Signaling and Neurological Disorders, Volume Seven, explores our current understanding of how chromatin signaling regulates access to genetic information, and how their aberrant regulation can contribute to neurological disorders. Researchers, students and clinicians will not only gain a strong grounding on the relationship between chromatin signaling and neurological disorders, but they'll also discover approaches to better interpret and employ new diagnostic studies and epigenetic-based therapies. A diverse range of chapters from international experts speaks to the basis of chromatin and epigenetic signaling pathways and specific chromatin signaling factors that regulate a range of diseases.
In addition to the basic science of chromatin signaling factors, each disease-specific chapter speaks to the translational or clinical significance of recent findings, along with important implications for the development of epigenetics-based therapeutics. Common themes of translational significance are also identified across disease types, as well as the future potential of chromatin signaling research.
Inhaltsverzeichnis
1. Chromatin and epigenetic signaling pathways
2. Non-pathologic neurological development
3. Spinal muscular atrophy
4. Triplet-Repeat Neurological Diseases
5. Amyotrophic Lateral Sclerosis
6. Charcot-Marie-Tooth disease
7. Parkinson's disease
8. Huntington's disease
9. Multiple Sclerosis
10. Ataxia Telangiectasia
11. Cockayne Syndrome neurodevelopmental disorders
12. Angelman Syndrome and Prader-Willi Syndrome
13. Rett Syndrome
14. Rubinstein-Taybi Syndrome
15. Sotos Syndrome
16. ATRX
17. Fragile X syndrome and mental retardation
18. Autism Spectrum Disorder and Asperger Syndrome
19. Schizophrenia
20. Gilles de la Tourette Syndrome
21. Alzheimer's disease (and other dementias)
22. Mood disorders
23. Attention deficit hyperactivity disorder (ADHD)
24. Obsessive compulsive disorder (OCD)
Über den Autor / die Autorin
Dr. Olivier Binda is a Researcher at the University of Ottawa, specializing in epigenetics and gene expression as it relates to human diseases. Dr. Binda co-edited Chromatin Signaling and Diseases (Elsevier 2016), a volume in Elsevier’s Translational Epigenetics series, and has published 20 scientific papers in such peer reviewed journals as the Molecular Cell, Journal of Biological Chemistry, Biochemistry, Epigenetics, Oncogene, Scientific Reports, and Stem Cell Research. In past positions he has served as a postdoctoral fellow at McGill University and Stanford University, and he completed his PhD in Biochemistry at McGill University in 2007.
Affiliations and expertise
University of Ottawa, Department of Cellular and Molecular Medicine, Ottawa, CANADA.
