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Zusatztext "It does successfully convey to the reader areas of controversy" (Microbiology Today! November 2001)"there are a number of nuggets in the book that make it worth a browse." (Pharmaceutical Physician! December 2001)"I found this book fun to read." (Biochemistry & Molecular Biology Education! No.29 2001)"Contributors...present 17 papers and the discussions they generated at the symposium." (SciTech Book News! Vol. 25! No. 4! December 2001) Informationen zum Autor The Novartis Foundation is an international scientific and educational charity which promotes the study and general knowledge of science and in particular encourages international co-operation in scientific research. Klappentext Der aktuelle Stand der Sequenzierungsverfahren wird hier von weltweit führenden Experten diskutiert. Daneben wird ein Ausblick auf neue Entwicklungen geboten, wobei der Schwerpunkt auf der Anwendung genetischer Informationen in der Wirkstofforschung liegt. Rechtliche und ethische Aspekte der Verwendung dieser Informationen werden ebenfalls angesprochen. (03/00) Zusammenfassung Functional genomics is the use of genetic information to design drugs. The ability to gather genetic data in the form of complete genetic sequences for certain organisms, has accelerated to astonishing speeds, reflecting the equally astonishing growth of information-gathering technologies. Inhaltsverzeichnis Introduction (J. Venter). Electrophoresis-Based Fluorescent Dideoxy-Terminator Sequencing (J. Efcavitch). Genomic Impact on Pharmaceutical Development (J. Venter). From Transcription Regulation to Cell Cycle Checkpoint (R. Cai, et al.). Mass Spectrometry Resurrects Protein-Approaches in Functional Genomics (M. Mann). A Clinical Molecular Scanner to Study Human Proteome Complexity (D. Hochstrasser, et al.). From Proteomics to Functional Analysis (J. van Oostrum, et al.). Microbial Genome Sequencing: New Insights into Physiology and Evolution (C. Fraser). Pharmacogenetics and Pharmacogenomics in the Discovery and Development of Medicines (A. Roses). Mutagenesis and Genomics in the Mouse: Towards Systematic Studies of Mammalian Gene Function (S. Brown). Biological Annotation of the Drosophila Genome Sequence (G. Rubin). Applications of High-Density Oligonucleotide Arrays (R. Lipshutz). Plasmodium Falciparum: From Genomic Sequence to Vaccines and Drugs (S. Hoffman & D. Carucci). Functional Analysis of the Yeast Genome by Precise Deletion and Parallel Phenotypic Characterization (E. Winzeler, et al.). Patenting Genes and Gene Therapy: Legal and Ethical Aspects (J. Straus). Ethical Issues: From Genome to Therapy (D. Magnus). The Impact of Genomics on Drug Discovery (P. Goodfellow). From Genome to Therapy: Industry Perspective (P. Herrling). Final General Discussion. Indexes....
Inhaltsverzeichnis
Introduction (J. Venter).
Electrophoresis-Based Fluorescent Dideoxy-Terminator Sequencing (J. Efcavitch).
Genomic Impact on Pharmaceutical Development (J. Venter).
From Transcription Regulation to Cell Cycle Checkpoint (R. Cai, et al.).
Mass Spectrometry Resurrects Protein-Approaches in Functional Genomics (M. Mann).
A Clinical Molecular Scanner to Study Human Proteome Complexity (D. Hochstrasser, et al.).
From Proteomics to Functional Analysis (J. van Oostrum, et al.).
Microbial Genome Sequencing: New Insights into Physiology and Evolution (C. Fraser).
Pharmacogenetics and Pharmacogenomics in the Discovery and Development of Medicines (A. Roses).
Mutagenesis and Genomics in the Mouse: Towards Systematic Studies of Mammalian Gene Function (S. Brown).
Biological Annotation of the Drosophila Genome Sequence (G. Rubin).
Applications of High-Density Oligonucleotide Arrays (R. Lipshutz).
Plasmodium Falciparum: From Genomic Sequence to Vaccines and Drugs (S. Hoffman & D. Carucci).
Functional Analysis of the Yeast Genome by Precise Deletion and Parallel Phenotypic Characterization (E. Winzeler, et al.).
Patenting Genes and Gene Therapy: Legal and Ethical Aspects (J. Straus).
Ethical Issues: From Genome to Therapy (D. Magnus).
The Impact of Genomics on Drug Discovery (P. Goodfellow).
From Genome to Therapy: Industry Perspective (P. Herrling).
Final General Discussion.
Indexes.
Bericht
"It does successfully convey to the reader areas of controversy" (Microbiology Today, November 2001)
"there are a number of nuggets in the book that make it worth a browse." (Pharmaceutical Physician, December 2001)
"I found this book fun to read." (Biochemistry & Molecular Biology Education, No.29 2001)
"Contributors...present 17 papers and the discussions they generated at the symposium." (SciTech Book News, Vol. 25, No. 4, December 2001)
