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This volume assembles and integrates the wealth of diverse information that is now accumulating in this burgeoning field. The existing and potential therapeutic applications of targeting CA cover a remarkably wide-range of diseases and disorders and have generated increasing and extensive interest in recent years. Its inter-disciplinary approach embraces both the most up-to-date therapeutic application of CA-targeting and the latest research data that will provide a platform for the development of novel applications. The interested audience comprises scientists and clinicians from many relevant disciplines within science and medicine.
Inhaltsverzeichnis
Dedication.- Preface.-The carbonic anhydrases in health and disease.- Carbonic anhydrase isozymes as diagnostic biomarkers and therapeutic targets.- Targeting carbonic anhydrases in vascular and pulmonary disease.- Carbonic anhydrase inhibitors in ophthalmology: glaucoma and macular oedema.- Targeting carbonic anhydrase isozymes in the treatment of neurological disorders.- Potential of carbonic anhydrase inhibitors in the treatment of oxidative stress and diabetes.- An overview of carbonic anhydrase-related neoplasms.- The carbonic anhydrase IX interactome and the regulation of cancer progression.- Carbonic anhydrase IX: current and emerging therapies.- Carbonic anhydrase inhibitors: designing isozyme-specific inhibitors as therapeutic agents.- Carbonic anhydrase inhibitors: identifying therapeutic cancer agents through virtual screening.- Targeting carbonic anhydrase IX in tumour imaging and theranostic cancer therapy.
