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The field of pediatric bone and soft tissue sarcomas has experienced a gradual but surprising transformation. Fundamental discoveries in the molecular biology of disease, recent breakthroughs in diagnostic imaging, and revolutionary surgical techniques have created unprecedented synergies and a refreshing vision with which to approach the diagnosis and treatment of these pediatric tumors. This book highlights the paths leading to the emergence of such a new vision and presents salient concepts in epidemiology, novel tools in imaging and molecular biology, and principles of drug development - as the scaffold to understanding the pathophysiology and treatment of pediatric sarcomas. The book provides an up-to-date comprehensive reference text that articulates a multidisciplinary approach for the diagnosis and treatment of each of these often challenging diseases.
Inhaltsverzeichnis
Epidemiology of Bone and Soft Tissue Sarcomas.- Pathologic and Molecular Techniques Used in the Diagnosis and Treatment Planning of Sarcomas.- Diagnostic Imaging of Pediatric Bone and Soft Tissue Sarcomas.- Local Control Issues in Pediatric Bone and Soft Tissue Sarcomas.- Drug Discovery in Pediatric Bone and Soft Tissue Sarcomas Using In Vivo Models.- Pediatric Rhabdomyosarcoma: Biology and Results of the North American Intergroup Rhabdomyosarcoma Trials.- Non-Rhabdomyosarcoma Soft Tissue Sarcomas.- Fibrous and Fibrohistiocytic Tumors.- Ewing Sarcoma Family of Tumors.- Osteosarcoma.
Zusammenfassung
The field of pediatric bone and soft tissue sarcomas has experienced a gradual but surprising transformation. Fundamental discoveries in the molecular biology of disease, recent breakthroughs in diagnostic imaging, and revolutionary surgical techniques have created unprecedented synergies and a refreshing vision with which to approach the diagnosis and treatment of these pediatric tumors. This book highlights the paths leading to the emergence of such a new vision and presents salient concepts in epidemiology, novel tools in imaging and molecular biology, and principles of drug development – as the scaffold to understanding the pathophysiology and treatment of pediatric sarcomas. The book provides an up-to-date comprehensive reference text that articulates a multidisciplinary approach for the diagnosis and treatment of each of these often challenging diseases.
