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The focus of this edited volume is to examine how Alzheimer's disease and vascular dementia, as well as their mild cognitive impairment analogs, are best viewed as a heterogeneous, intersecting, if not a continuous disease state rather than separate, distinct entities. This book examines this approach by providing empirically based evidence, reviews of the literature, and chapters by key leaders in the field and will be of interest to clinical neuropsychologists and anyone studying or treating dementia in its many forms.
Inhaltsverzeichnis
- Preface
- Part 1: Epidemiology and Neuropsychology
- Chapter 1: Vascular risk factors and their relationship to brain aging: Findings from the Framingham Heart Study
- Chapter 2: Neuropsychological Profiles in Alzheimer's/ Vascular Spectrum Dementia
- Chapter 3: Neuropsychological Diagnostic Criteria for Mild Cognitive Impairment due to Alzheimer's Disease
- Chapter 4: Vascular Cognitive Impairment
- Chapter 5: Decline in Everyday Functioning in MCI and Dementia: A Neuropsychological Perspective
- Chapter 6: Heterogeneity in Dementia and MCI: Using Statistical Modeling Techniques
- Chapter 7: Apraxic and Action-Intentional Disorders Associated With Vascular And Degenerative Dementing Diseases
- Part 2: Neuroimaging
- Chapter 8: Cerebral small vessel disease and the risk of dementia and cognition decline
- Chapter 9: Structural MRI in Alzheimer's disease: Are we measuring the right stuff
- Chapter 10: Advances in Multi-Modal Imaging Across the Spectrum of Normal to Pathological aging: Incorporating Vascular Comorbidities Common to Alzheimer's disease and Vascular Dementia
- Part 3: Blood-Brain-Barrier and Cardiogenic Mechanisms
- Chapter 11: The Blood-Brain Barrier in Cognitive Decline and Alzheimer's Disease
- Chapter 12: Arterial Stiffening and Cerebrovascular Resistance in Cognitive Decline and Alzheimer's Disease
- Chapter 13: Hemodynamics in Alzheimer's Disease and Vascular Cognitive Impairment and Dementia
- Part 4: Neuropathological and Neurophysiological Mechanisms
- Chapter 14: Neuropathology of AD/ VaD Dementia
- Chapter 15: Potential of blood- and CSF-based biomarkers for AD diagnostics
- Chapter 16: Unravelling the Role of Mitochondria in Alzheimer's disease: Toward Assembling the Puzzle
- Part 5: Treatment and Intervention
- Chapter 17: Dementia and Elective Surgeries: Considerations for Neuropsychologists
- Chapter 18: Management of Mild Cognitive Impairment
Über den Autor / die Autorin
David J. Libon is Professor of Geriatrics, Gerontology, and Psychology at the New Jersey Institute for Successful Aging, School of Osteopathic Medicine, Rowan University.
Melissa Lamar is a licensed Clinical Neuropsychologist and an Associate Professor in the Department of Behavioral Sciences and a full-time Cognitive Neuroscientist within the Rush Alzheimer's Disease Center at the Rush University Medical Center.
Rodney A. Swenson is a board certified Neuropsychologist and Clinical Professor of Psychiatry and Behavioral Science, University of North Dakota School of Medicine and Health Sciences.
Kenneth M. Heilman is a Distinguished Professor Emeritus at the University of Florida.
Zusammenfassung
Alzheimer's disease (AD) and vascular dementia (VaD) are commonly viewed as the first and second most common types of dementia, respectively. The traditional paradigm has been to view and treat each illness as a separate entity with a separate pathophysiology. However, clinical and pathological studies suggest that the boundary separating AD and VaD, as well as their mild cognitive impairment (MCI) analogs, is not well defined. Thus, there is increased interest in viewing these diseases along a spectrum because of the significant overlap in the characterization and diagnosis of AD, VaD, and MCI. The focus of this edited volume is to examine how AD and VaD, as well as their MCI analogs, are best viewed as a heterogeneous, intersecting, if not a continuous disease state rather than separate, distinct entities. This book examines this approach by providing empirically based evidence, reviews of the literature, and chapters by key leaders in the field and will be of interest to clinical neuropsychologists and anyone studying or treating dementia in its many forms.
Zusatztext
In this book, world-leaders in the area summarize current knowledge on the heterogeneity of Alzheimer's disease, vascular dementia, and mild cognitive impairment, and how these conditions are on a continuum and influence and shape the expression of each other. This book is a must for researchers, clinicians, and others interested in the heterogeneity and overlap of the most common forms of cognitive decline, and will be a standard reference for many years."
-Ingmar Skoog, Professor, Institute of Neuroscience and Physiology and Director of the Centre for Ageing and Health, AgeCap, University of Gothenburg, Sweden
