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This volume looks into the need for a variety of experimental models for research on traumatic brain injury (TBI) and peripheral nervous system. It also describes a number of experimental models, such as mechanical devices, that have been developed to model neurotrauma in animal experiments. The overall aim of this book is to explore the variety of models and how they are used in current research. The chapters in this book are organized in four sections and talk about animal models for TBI; animal models for spinal cord or nerve injury; and translational aspects, secondary injuries, in vitro studies, and evaluation of large data sets. In Neuromethods series style, chapters include the kind of detail and key advice from the specialists needed to get successful results in your laboratory.
Cutting-edge and comprehensive, Animal Models of Neurotrauma is a valuable resource for researchers interested in expanding their knowledge and research in this developing field.
Inhaltsverzeichnis
The Fluid Percussion Injury Rodent Model in Preclinical Research on Traumatic Brain Injury.- Focal and Restricted Traumatic Injury Models in the Rodent Brain-Limitations, Possibilities, and Challenges.- A Model for Research on Penetrating Traumatic Brain Injuries.- A Sagittal Plane Rotational Injury Rodent Model for Research on Traumatic Brain Injuries.- Experimental Models of Blast-Induced Neurotrauma.- Utilization of Shock Tubes in Blast Injury Research.- Introduction to Blast in the Context of Blast Induced TBI.- The Clemedson Blast Tube.- Traumatic Peripheral Nerve Injuries - Experimental Models for Repair and Reconstruction.- CNS Regeneration in Nerve Grafts - Practical Aspects of Complete Thoracic Spinal Cord Injury in Rodents.- Experimental Nerve Plexus Root Avulsion and Spinal Cord Implantation.- Surgical Replantation of Avulsed Lumbosacral Ventral Roots and Urodynamic Studies in a Rhesus Macaque (Macaca mulatta) Modelof Cauda Equina/Conus Medullaris Injury and Repair.- Secondary Insults in Experimental Traumatic Brain Injury - The Addition of Hypoxia.- A Translational Model of Traumatic Brain Injury: Sheep Impact Acceleration.- In Vitro Trauma - Description of a Cavitation Inducing Injury Model.- Clinically Relevant Outcome Measures for Experimental Traumatic Brain Injury (TBI) Studies.- Concluding Remarks.
Zusammenfassung
This volume looks into the need for a variety of experimental models for research on traumatic brain injury (TBI) and peripheral nervous system. It also describes a number of experimental models, such as mechanical devices, that have been developed to model neurotrauma in animal experiments. The overall aim of this book is to explore the variety of models and how they are used in current research. The chapters in this book are organized in four sections and talk about animal models for TBI; animal models for spinal cord or nerve injury; and translational aspects, secondary injuries, in vitro studies, and evaluation of large data sets. In Neuromethods series style, chapters include the kind of detail and key advice from the specialists needed to get successful results in your laboratory.
Cutting-edge and comprehensive, Animal Models of Neurotrauma is a valuable resource for researchers interested in expanding their knowledge and research in this developing field.
