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This work represents an inventive attempt to apply recent advances in nanotechnology to identify and characterise novel polymer systems for drug delivery through the skin. Atomic force microscopy (AFM) measurements of the nanoscale mechanical properties of topical, drug-containing polymeric films enabled the author to identify optimal compositions, in terms of flexibility and substantivity, for application to the skin. To elucidate the enhanced drug release from polyacrylate films incorporating medium chain triglycerides, the author combined AFM studies with the complementary technique of Raman micro-spectroscopy. This experimental strategy revealed that the significant increase in the drug released from these films is the result of a nanoscale two-phase structure. Finally, in experiments examining the microporation of skin using femtosecond laser ablation, the author demonstrated that the threshold at which the skin's barrier function is undermined can be dramatically reduced by the pre-application of ink. The approach allows thermal damage at the pore edge to be minimised, suggesting a very real potential for substantially increasing drug delivery in a minimally invasive fashion.
Inhaltsverzeichnis
Introduction.-Background.- Methodology.- TEC Plasticization of Topical Polymeric Films.- Lipid Incorporation into Topical PolymericFilms.- Laser Microporation of Skin.- Conclusion.
Über den Autor / die Autorin
Hazel
Garvie-Cook received her M.Phys degree in Physics from Durham
University in 2011 and a PhD in (trans)dermal drug delivery
strategies from the University of Bath in 2014. Since finishing her
PhD, she has stayed on at the University of Bath as a Research
Associate in the Department of Pharmacy & Pharmacology. Her
research interests include imaging techniques for investigating drug
delivery to the skin and the changes in topical formulations
post-application.
Zusammenfassung
This work represents an inventive attempt to apply recent advances in
nanotechnology to identify and characterise novel polymer systems for
drug delivery through the skin. Atomic
force microscopy (AFM) measurements of the nanoscale mechanical
properties of topical, drug-containing polymeric films enabled the
author to identify optimal compositions, in terms of flexibility and
substantivity, for application to the skin. To elucidate
the enhanced drug release from polyacrylate films incorporating medium
chain triglycerides, the author combined AFM studies with the
complementary technique of Raman micro-spectroscopy. This experimental
strategy revealed that the significant increase in the
drug released from these films is the result of a nanoscale two-phase
structure. Finally, in experiments examining the microporation of skin
using femtosecond laser ablation, the author demonstrated that the
threshold at which the skin's barrier function
is undermined can be dramatically reduced by the pre-application of
ink. The approach allows thermal damage at the pore edge to be
minimised, suggesting a very real potential for substantially increasing
drug delivery in a minimally invasive fashion.
