Systems Analysis of Human Multigene Disorders

Understanding the genetic architecture underlying complex multigene disorders is one of the major goals of human genetics in the upcoming decades. Advances in whole genome sequencing and the success of high throughput functional genomics allow supplementing conventional reductionist biology with systems-level approaches to human heredity and health as systems of interacting genetic, epigenetic, and environmental factors. This integrative approach holds the promise of unveiling yet unexplored levels of molecular organization and biological complexity. It may also hold the key to deciphering the multigene patterns of disease inheritance.

Inhaltsverzeichnis

Wellness and Health Omics Linked to the Environment: the WHOLE approach to personalized medicine.- Characterizing Multi-omic Data in Systems Biology.- High-throughput Translational Medicine: Challenges and Solutions.- Computational approaches for human disease gene prediction and ranking.- A Personalized Treatment for Lung Cancer: Molecular Pathways, Targeted Therapies, and Genomic Characterization.- Index.

Zusammenfassung

Understanding the genetic architecture underlying complex multigene disorders is one of the major goals of human genetics in the upcoming decades. Advances in whole genome sequencing and the success of high throughput functional genomics allow supplementing conventional reductionist biology with systems-level approaches to human heredity and health as systems of interacting genetic, epigenetic, and environmental factors. This integrative approach holds the promise of unveiling yet unexplored levels of molecular organization and biological complexity. It may also hold the key to deciphering the multigene patterns of disease inheritance.

Produktdetails

• Mitarbeit: T Conrad Gilliam (Herausgeber), T. Conrad Gilliam (Herausgeber), Natalia Maltsev (Herausgeber), Andre Rzhetsky (Herausgeber), Andrey Rzhetsky (Herausgeber)
• Verlag: Springer, Berlin
• Sprache: Englisch
• Produktform: Taschenbuch
• Erschienen: 01.01.2017
• EAN: 9781493951949
• ISBN: 978-1-4939-5194-9
• Seiten: 122
• Abmessung: 155 mm x 6 mm x 235 mm
• Gewicht: 243 g
• Illustration: XIII, 122 p. 12 illus. in color.
• Serien: Advances in Experimental Medicine and Biology; Advances in Experimental Medic; Advances in Experimental Medic; Advances in Experimental Medicine and Biology
• Themen: Naturwissenschaften, Medizin, Informatik, Technik > Biologie > Sonstiges; B, Human Genetics, Biomedical and Life Sciences, Medical Genetics, Systems Biology, Computational and Systems Biology